Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70888
標題: New, general, and practical preparation of methyl ketones via the direct coupling of amides with CH(2)Cl(2) promoted by TiCl(4)/Mg
作者: Lin, K.W.
Tsai, C.H.
Hsieh, I.L.
Yan, T.H.
關鍵字: direct conversion
carboxylic-acids
esters
methylenation
aldehydes
efficient
reagents
chlorotrimethylsilane
dichloromethane
1,4-diketones
期刊/報告no:: Organic Letters, Volume 10, Issue 10, Page(s) 1927-1930.
摘要: The direct coupling of a variety of amides with CH(2)Cl(2) or CD(2)Cl(2) promoted by TiCl(4)/Mg/THF provides an extremely simple, practical, selective, and efficient approach for the construction of methyl ketones. The efficiency and practicability of this chemistry is illustrated by the very simple synthesis of deuterated methyl ketones.
URI: http://hdl.handle.net/11455/70888
ISSN: 1523-7060
文章連結: http://dx.doi.org/10.1021/ol8004326
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