Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70923
標題: Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells
作者: Hsu, J.C.
Lin, L.C.
Tzen, J.T.C.
Chen, J.Y.
期刊/報告no:: Peptides, Volume 32, Issue 6, Page(s) 1110-1116.
摘要: Pardaxin, a pore-forming antimicrobial peptide that encodes 33 amino acids was isolated from the Red Sea Moses sole, Pardachirus mamoratus. In this study, we investigated its antitumor activity in human fibrosarcoma (HT-1080) cells and epithelial carcinoma (HeLa) cells. In vitro results showed that the synthetic pardaxin peptide had antitumor activity in these two types of cancer cells and that 15 mu g/ml pardaxin did not lyse human red blood cells. Moreover, this synthetic pardaxin inhibited the proliferation of HT1080 cells in a dose-dependent manner and induced programmed cell death in HeLa cells. DNA fragmentation and increases in the subG1 phase and caspase 8 activities suggest that pardaxin caused HeLa cell death by inducing apoptosis, but had a different mechanism in HT1080 cells. (C) 2011 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/70923
ISSN: 0196-9781
文章連結: http://dx.doi.org/10.1016/j.peptides.2011.04.024
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