請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/70989
標題: Age-series characteristics of locomotor activities in spontaneously hypertensive rats: A comparison with the Wistar-Kyoto strain
作者: Hsieh, Y.L.
Yang, C.C.
關鍵字: spontaneously hypertensive rats
Wistar-Kyoto
behavioral specificities
locomotor activity
longitudinal study
deficit hyperactivity disorder
attention-deficit/hyperactivity
disorder
open-field behavior
animal-model
automated measurement
reactivity
shr
exploration
stress
lesion
期刊/報告no:: Physiology & Behavior, Volume 93, Issue 4-5, Page(s) 777-782.
摘要: This study was to investigate the behavioral specificities of spontaneously hypertensive rats (SHR) and compare them with Wistar-Kyoto (WKY) controls using a I-year longitudinal study of locomotor activity. Rat locomotor activity was examined every week at 4-12 weeks of age and every month at 4-12 months of age using an Automated Digiscan Activity Monitor system. Six behavioral variables were collected and analyzed: horizontal activity (HA), total distance (TD), movement time (MT), vertical activity (VA), stereotypy count (SC), and margin time (MGT). In general, a significant weekly and monthly age-dependent change (p 0.01) in SHR was shown in the HA, TD, VA, SC and MT variables, whereas MGT showed no significant differences (p>0.05). However, except for the first observations, SHR was significantly hyperactive relative to WKY for HA, VA, TD, MT and SC (p<0.01) before 6 months of age. MGT in SHR were significantly lower than those of WKY (p<0.01) before 3 months of age. Only for VA, SHR was more hyperactive than WKY (p<0.01) and sustained for 12 months in age. From the present results, by extending the observations of locomotor activity testing from 4 weeks to 12 months of life, we were able to observe an interesting strain difference between SHR and WKY in the development pattern of spontaneous activity levels. (c) 2007 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/70989
ISSN: 0031-9384
文章連結: http://dx.doi.org/10.1016/j.physbeh.2007.11.032
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