請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/70993
標題: Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model
作者: Ho, Y.T.
Yang, J.S.
Lu, C.C.
Chiang, J.H.
Li, T.C.
Lin, J.J.
Lai, K.C.
Liao, C.L.
Lin, J.G.
Chung, J.G.
關鍵字: Berberine
Human tongue SCC-4 cancer cells
Xenograft transplantation
In vivo
cells
apoptosis
pathway
期刊/報告no:: Phytomedicine, Volume 16, Issue 9, Page(s) 887-890.
摘要: Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10 mg/kg of body weight) and doxorubicin (4 mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4 mg/kg of doxorubicin or with 10 mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10 mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic. (c) 2009 Elsevier GmbH. All rights reserved.
URI: http://hdl.handle.net/11455/70993
ISSN: 0944-7113
文章連結: http://dx.doi.org/10.1016/j.phymed.2009.02.015
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