Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71228
標題: Evaluation of a new inflammatory molecule (triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion
作者: Chan, M.C.
Chang, K.M.
Chao, W.C.
Lin, L.Y.
Kuo, B.I.T.
Hsu, J.Y.
Wu, C.L.
關鍵字: para-pneumonic effusion
pleural effusion
triggering receptor expressed
on myeloid cell-1
turberculous pleuritis
immune-response
septic shock
tuberculous pleuritis
sepsis
pneumonia
patterns
surface
trem-1
lung
期刊/報告no:: Respirology, Volume 12, Issue 3, Page(s) 333-338.
摘要: Background and objective: The triggering receptor expressed on myeloid cell-1 (TREM-1) is a newly discovered molecule that is associated with the inflammatory response to microorganisms. We investigated the role of surface and soluble TREM-1 in differentiating different disease entities in pleural effusion formation. Methods: Sixty-seven patients with pleural effusion due to transudate (14), malignancy (15), tuberculous pleuritis (16), para-pneumonic effusion (10) and empyaema (12) were included in this study. Surface TREM-1 was measured by flow cytometry and was expressed as mean fluorescence intensity and soluble TREM-1 was measured by ELISA and expressed as pg/mL. Results are given as mean levels SEM. Results: Surface TREM-1 was measured in 24 patients and the levels were highest in parapneumonic effusion (30.0 +/- 8.4) and lowest in malignant pleural effusion (5.2 +/- 1. 1) and tuberculous pleuritis (5.2 +/- 2.4). Soluble TREM-1 was highest in effusions of infectious aetiology (para-pneumonic effusion (979.4 +/- 229.6) and empyaema (1712.6 +/- 299.5)) and lowest in non-infectious effusions (transudate (81.2 +/- 4.5 pg/mL) and malignancy R 11.3 +/- 20.7). At a cut-off value of 114 pg/mL, soluble TREM-1 yielded a sensitivity of 87.5% and a specificity of 89.7% in differentiating non-infectious effusion from tuberculous pleuritis. At a cut-off value of 374 pg/mL, sTREM-1 yielded a sensitivity of 93.8% and a specificity of 90.9 in differentiating tuberculous pleuritis from bacterial pleural effusion. Conclusion: Soluble and surface TREM-1 are valuable markers in establishing the aetiology of pleural effusions.
URI: http://hdl.handle.net/11455/71228
ISSN: 1323-7799
文章連結: http://dx.doi.org/10.1111/j.1400-1843.2007.01056.x
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