Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71386
標題: Synthesis of Allenes via Nickel-Catalyzed Cross-Coupling Reaction of Propargylic Bromides with Grignard Reagents
作者: Li, Q.H.
Gau, H.M.
關鍵字: allenes
nickel
propargylic bromide
Grignard reagent
cross-coupling
one-pot synthesis
hydride-transfer reaction
axially chiral allenes
substituted allenes
1,3-disubstituted allenes
organic-synthesis
enantioselective synthesis
stereospecific synthesis
asymmetric-synthesis
general-route
期刊/報告no:: Synlett, Issue 5, Page(s) 747-750.
摘要: We describe a convenient method for the synthesis of terminal allenes from cross-coupling of propargylic bromide with Grignard reagent. The reaction of propargylic bromide with 1.2 equivalents of Grignard reagent mediated by Ni(acac)(2) (2 mol%) and Ph3P (4 mol%) in THF may produce terminal allenes in good yields and high regioselectivities at room temperature.
URI: http://hdl.handle.net/11455/71386
ISSN: 0936-5214
文章連結: http://dx.doi.org/10.1055/s-0031-1290365
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