Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71418
標題: Asymmetric bromination-aldolization of chiral acetate titanium enolate derived from thioimide. A general approach to the synthesis of enantiopure alpha-bromo-beta-hydroxy carboxylic acids
作者: Wang, Y.C.
Su, D.W.
Lin, C.M.
Tseng, H.L.
Li, C.L.
Yan, T.H.
關鍵字: Aldol reactions
asymmetric induction
enolates
halohydrins
aldol reactions
condensation
assemblage
期刊/報告no:: Tetrahedron Letters, Volume 40, Issue 18, Page(s) 3577-3580.
摘要: Chiral acetate titanium enolate derived from thioimide efficiently effects one-step bromination-aldolization with excellent yields and exceptionally high levels of asymmetric induction in aldol additions. General base promoted oxazolidinethione deacylation provides direct access to chiral alpha-bromo-beta-hydroxy acids. (C) 1999 Elsevier Science Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/71418
ISSN: 0040-4039
文章連結: http://dx.doi.org/10.1016/s0040-4039(99)00576-6
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