Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71509
標題: Polymorphisms of cytotoxic T lymphocyte-associated antigen-4 and cytokine genes in Taiwanese patients with ankylosing spondylitis
作者: Lee, W.Y.
Chang, Y.H.
Lo, M.K.
Chang, C.P.
Yang, S.C.
Yang, T.P.
Ho, K.T.
Juan, C.W.
Shiau, M.Y.
關鍵字: ankylosing spondylitis
cytotoxic T lymphocyte-associated antigen-4
genetic polymorphisms
interleukin-4
interleukin-6
interleukin-10
type-2 diabetes-mellitus
factor-alpha promoter
rheumatoid-arthritis
graves-disease
ctla-4
interleukin-10
susceptibility
population
variants
hla-b27
期刊/報告no:: Tissue Antigens, Volume 75, Issue 2, Page(s) 119-126.
摘要: Cytokines, costimulatory and counter-regulatory molecules play important roles in the regulation of inflammatory response, and are good candidates involved in the development of ankylosing spondylitis (AS). This study investigated the genotypic distribution of proinflammatory cytokines and T-cell negative regulator cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in healthy subjects and AS patients. Genomic DNA was extracted from 143 AS patients and 166 ethnic-matched healthy subjects. Nine polymorphisms within the genes of interleukin-4 (IL-4) (-34T > C, -81A > G, -285C > T and -589T > C), interleukin-6 (IL-6) (-174G > C), interleukin-10 (IL-10) (-592A > C and -819T > C) and CTLA-4 (-318C > T and +49A > G) were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significantly less AS patients carried the CTLA-4 high-expressing -318 T allele (P = 0.040). The CTLA-4 +49A > G genotypes were associated with circulatory levels of the inflammatory marker C-reactive protein (CRP) (P = 0.022). Our study documented the most complete genetic information of Taiwanese AS patients. The observations that CTLA-4 +49A > G genotypes are associated with circulatory CRP levels and significantly less AS subjects carrying CTLA-4 higher-secretor -318 T allele suggest the level and regulation of inflammation in AS subjects may be pre-determined by and associated with CTLA-4 genotypes.
URI: http://hdl.handle.net/11455/71509
ISSN: 0001-2815
文章連結: http://dx.doi.org/10.1111/j.1399-0039.2009.01411.x
Appears in Collections:期刊論文

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.