Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/71509
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dc.contributor.authorLee, W.Y.en_US
dc.contributor.authorChang, Y.H.en_US
dc.contributor.authorLo, M.K.en_US
dc.contributor.authorChang, C.P.en_US
dc.contributor.authorYang, S.C.en_US
dc.contributor.authorYang, T.P.en_US
dc.contributor.authorHo, K.T.en_US
dc.contributor.authorJuan, C.W.en_US
dc.contributor.authorShiau, M.Y.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-11T06:01:48Z-
dc.date.available2014-06-11T06:01:48Z-
dc.identifier.issn0001-2815zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/71509-
dc.description.abstractCytokines, costimulatory and counter-regulatory molecules play important roles in the regulation of inflammatory response, and are good candidates involved in the development of ankylosing spondylitis (AS). This study investigated the genotypic distribution of proinflammatory cytokines and T-cell negative regulator cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in healthy subjects and AS patients. Genomic DNA was extracted from 143 AS patients and 166 ethnic-matched healthy subjects. Nine polymorphisms within the genes of interleukin-4 (IL-4) (-34T > C, -81A > G, -285C > T and -589T > C), interleukin-6 (IL-6) (-174G > C), interleukin-10 (IL-10) (-592A > C and -819T > C) and CTLA-4 (-318C > T and +49A > G) were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significantly less AS patients carried the CTLA-4 high-expressing -318 T allele (P = 0.040). The CTLA-4 +49A > G genotypes were associated with circulatory levels of the inflammatory marker C-reactive protein (CRP) (P = 0.022). Our study documented the most complete genetic information of Taiwanese AS patients. The observations that CTLA-4 +49A > G genotypes are associated with circulatory CRP levels and significantly less AS subjects carrying CTLA-4 higher-secretor -318 T allele suggest the level and regulation of inflammation in AS subjects may be pre-determined by and associated with CTLA-4 genotypes.en_US
dc.language.isoen_USzh_TW
dc.relationTissue Antigensen_US
dc.relation.ispartofseriesTissue Antigens, Volume 75, Issue 2, Page(s) 119-126.en_US
dc.relation.urihttp://dx.doi.org/10.1111/j.1399-0039.2009.01411.xen_US
dc.subjectankylosing spondylitisen_US
dc.subjectcytotoxic T lymphocyte-associated antigen-4en_US
dc.subjectgenetic polymorphismsen_US
dc.subjectinterleukin-4en_US
dc.subjectinterleukin-6en_US
dc.subjectinterleukin-10en_US
dc.subjecttype-2 diabetes-mellitusen_US
dc.subjectfactor-alpha promoteren_US
dc.subjectrheumatoid-arthritisen_US
dc.subjectgraves-diseaseen_US
dc.subjectctla-4en_US
dc.subjectinterleukin-10en_US
dc.subjectsusceptibilityen_US
dc.subjectpopulationen_US
dc.subjectvariantsen_US
dc.subjecthla-b27en_US
dc.titlePolymorphisms of cytotoxic T lymphocyte-associated antigen-4 and cytokine genes in Taiwanese patients with ankylosing spondylitisen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1111/j.1399-0039.2009.01411.xzh_TW
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