請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/71585
標題: Rapamycin Protects Against High Fat Diet-Induced Obesity in C57BL/6J Mice
作者: Chang, G.R.
毛嘉洪
Chiu, Y.S.
Wu, Y.Y.
Chen, W.Y.
Liao, J.W.
Chao, T.H.
Mao, F.C.
廖俊旺
關鍵字: rapamycin
obesity
food intake
adipose tissue
leptin
renal-transplant recipients
mammalian target
insulin-resistance
food-intake
transcriptional regulation
adipocyte differentiation
signaling network
leptin resistance
neural functions
skeletal-muscle
期刊/報告no:: Journal of Pharmacological Sciences, Volume 109, Issue 4, Page(s) 496-503.
摘要: Rapamycin (RAPA), an immunosuprpressive drug used extensively to prevent graft rejection in transplant patients, has been reported to inhibit adipogenesis in vitro. In this study, we investigated the anti-obesity effects of RAPA in C57BL/6J mice on a high-fat diet (HFD). Mice treated with RAPA (2 mg/kg per week for 16 weeks) had reduced body weight and epididymal fat pads/body weight, reduced daily food efficiency, and lower serum leptin and insulin levels compared with the HFD control mice. However, RAPA-treated mice were hyperphagic, demonstrating an increase in food intake. Dissection of RAPA-treated mice revealed a marked reduction in fatty liver scores, average fat cell size, and percentage of large adipocytes of retroperitoneal and epididymal white adipose tissue (RWAT and EWAT), compared to the HFD control mice. These results Suggest that RAPA prevented the effect of the high-fat diet on the rate of accretion in body weight via reducing lipid accumulation, despite greater food intake. It is likely that RAPA may serve as a potential strategy for body weight control and/or anti-obesity therapy.
URI: http://hdl.handle.net/11455/71585
ISSN: 1347-8613
文章連結: http://dx.doi.org/10.1254/jphs.08215FP
顯示於類別:獸醫學院

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。