請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/71589
標題: Chromium attenuates hepatic damage in a rat model of chronic cholestasis
作者: Chen, W.Y.
毛嘉洪
Chen, C.J.
Liao, J.W.
Mao, F.C.
廖俊旺
關鍵字: Cholestasis
Chromium
Hepatotoxicity
Oxidative stress
type-2 diabetes-mellitus
duct-ligated rat
lipid-peroxidation
liver
fibrosis
matrix metalloproteinases
carbon-tetrachloride
oxidative
stress
trace quantities
supplementation
glucose
期刊/報告no:: Life Sciences, Volume 84, Issue 17-18, Page(s) 606-614.
摘要: Aims: Oxidative stress is involved in cholestasis-induced hepatic damage. Therefore, antioxidant therapy is a recommended therapeutic strategy. Studies have illustrated that chromium can enhance antioxidative capacity leading to a resolution of oxidative stress. The aim of this study was to assess whether chromium has protective effects against cholestasis-related liver damage. Main methods: Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3 weeks. Rats were randomly divided into four groups. Control and BDL groups were subjected to sham and BDL operation, respectively, and were supplemented with placebo for 3 weeks. The BDL-post Cr group was supplemented with chromium chloride for 3 weeks after BDL operation. The BDL-pre Cr group was supplemented with chromium chloride for 6 weeks starting from 3 weeks before BDL operation. Key findings: In comparison with the control group, the BDL group showed hepatic damage as evidenced by elevation in serum biochemicals, ductular reaction, and fibrosis. These pathophysiological changes were attenuated in the BDL-Pre Cr and BDL-Post Cr groups. However, there was no significant difference between these two groups. The anti-fibrotic effect of chromium was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of transforming growth factor beta 1 (TGF-beta 1). In addition, chromium effectively attenuated BDL-induced hepatic oxidative stress. Significance: The data indicate that chromium attenuates BIDL-induced cholestatic liver injury, bile duct proliferation, and fibrosis. The hepatoprotective effect of chromium is associated with antioxidative potential. (C) 2009 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/71589
ISSN: 0024-3205
文章連結: http://dx.doi.org/10.1016/j.lfs.2009.02.003
顯示於類別:獸醫學院

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。