請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/85001
標題: Concise synthesis of α-galactosyl ceramide from d-galactosyl iodide and d-lyxose
關鍵字: α-Galactosyl ceramide
KRN7000
Glycosyl iodide
One-pot protection-glycosylation
Wittig reaction
摘要: α-Galactosyl ceramide is synthesized from d-lyxose in 32% overall yield in five steps. The short and efficient protocol involves a one-pot protection and glycosidation of d-lyxose with d-galactosyl iodide as a key step. The α-linked disaccharide obtained was subsequently transformed into α-galactosyl ceramide in four steps involving Z-selective Wittig olefination at C-1, stereo-inversion at C-4 using azide, one-pot reduction of azide and amidation, and global deprotection.
URI: http://hdl.handle.net/11455/85001
文章連結: http://dx.doi.org/10.1016/j.carres.2012.11.008
顯示於類別:化學系所

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