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標題: DPRP: a database of phenotype-specific regulatory programs derived from transcription factor binding data
作者: Tzeng, David T W
Tseng, Yu-Ting
Ung, Matthew
Liao, I-En
Liu, Chun-Chi
Cheng, Chao
關鍵字: Algorithms
Binding Sites
Transcription Factors
Databases, Genetic
Gene Expression Profiling
Gene Regulatory Networks
摘要: Gene expression profiling has been extensively used in the past decades, resulting in an enormous amount of expression data available in public databases. These data sets are informative in elucidating transcriptional regulation of genes underlying various biological and clinical conditions. However, it is usually difficult to identify transcription factors (TFs) responsible for gene expression changes directly from their own expression, as TF activity is often regulated at the posttranscriptional level. In recent years, technical advances have made it possible to systematically determine the target genes of TFs by ChIP-seq experiments. To identify the regulatory programs underlying gene expression profiles, we constructed a database of phenotype-specific regulatory programs (DPRP, derived from the integrative analysis of TF binding data and gene expression data. DPRP provides three methods: the Fisher's Exact Test, the Kolmogorov-Smirnov test and the BASE algorithm to facilitate the application of gene expression data for generating new hypotheses on transcriptional regulatory programs in biological and clinical studies.
ISSN: 1362-4962
Appears in Collections:基因體暨生物資訊學研究所



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