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標題: miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
作者: Hsu, Sheng-Da
Tseng, Yu-Ting
Shrestha, Sirjana
Lin, Yu-Ling
Khaleel, Anas
Chou, Chih-Hung
Chu, Chao-Fang
Huang, Hsi-Yuan
Lin, Ching-Min
Ho, Shu-Yi
Jian, Ting-Yan
Lin, Feng-Mao
Chang, Tzu-Hao
Weng, Shun-Long
Liao, Kuang-Wen
Liao, I-En
Liu, Chun-Chi
Huang, Hsien-Da
關鍵字: Disease
Gene Expression Regulation
High-Throughput Nucleotide Sequencing
RNA, Messenger
Sequence Analysis, RNA
Databases, Nucleic Acid
摘要: MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database ( provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
ISSN: 1362-4962
Appears in Collections:基因體暨生物資訊學研究所



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