Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/86424
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dc.contributor.authorChen, Wen-Yingzh_TW
dc.contributor.authorHuang, Yi-Chunzh_TW
dc.contributor.authorYang, Ming-Lingzh_TW
dc.contributor.authorLee, Chien-Yingzh_TW
dc.contributor.authorChen, Chun-Jungzh_TW
dc.contributor.authorYeh, Chung-Hsinzh_TW
dc.contributor.authorPan, Pin-Hozh_TW
dc.contributor.authorHorng, Chi-Tingzh_TW
dc.contributor.authorKuo, Wu-Hsienzh_TW
dc.contributor.authorKuan, Yu-Hsiangzh_TW
dc.date2014-
dc.date.accessioned2015-08-04T03:29:27Z-
dc.date.available2015-08-04T03:29:27Z-
dc.identifier.issn15675769zh_TW
dc.identifier.issn1878-1705zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/86424-
dc.description.abstractLipopolysaccharide (LPS), also called endotoxin, is the important pathogen of acute lung injury (ALI), which is a clinical syndrome that still lacks effective therapeutic medicine. Rutin belongs to vitamin P and possesses various beneficial effects. In this study, we investigate the potential protective effects and the mechanisms of rutin on LPS-induced ALI. Pre-administration with rutin inhibited LPS-induced arterial blood gas exchange and neutrophils infiltration in the lungs. LPS-induced expression of macrophage inflammatory protein (MIP)-2 and activation of matrix metalloproteinase (MMP)-9 were suppressed by rutin. In addition, the inhibitory concentration of rutin on phosphorylation of Akt was similar as MIP-2 expression and MMP-9 activation. In conclusion, rutin is a potential protective agent for ALI via suppressing the blood gas exchange and neutrophil infiltration. The mechanism of rutin is down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation.zh_TW
dc.language.isoenzh_TW
dc.relationInternational Immunopharmacology, Volume 22, Issue 2, Page(s) 409-413.zh_TW
dc.subjectAcute lung injuryzh_TW
dc.subjectAktzh_TW
dc.subjectLPSzh_TW
dc.subjectMIP-2zh_TW
dc.subjectMMP-9zh_TW
dc.subjectRutinzh_TW
dc.subjectAcute Lung Injuryzh_TW
dc.subjectAnimalszh_TW
dc.subjectBronchoalveolar Lavage Fluidzh_TW
dc.subjectChemokine CXCL2zh_TW
dc.subjectDown-Regulationzh_TW
dc.subjectLipopolysaccharideszh_TW
dc.subjectLungzh_TW
dc.subjectMatrix Metalloproteinase 9zh_TW
dc.subjectMicezh_TW
dc.subjectNeutrophil Infiltrationzh_TW
dc.subjectPhosphorylationzh_TW
dc.subjectProtective Agentszh_TW
dc.subjectProto-Oncogene Proteins c-aktzh_TW
dc.subjectRutinzh_TW
dc.titleProtective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylationzh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.intimp.2014.07.026zh_TW
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