Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/86426
標題: Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity
作者: Li, Shiming
Lin, Yi-Chin
Ho, Chi-Tang
Lin, Ping-Yi
Suzawa, Michiko
Wang, Hsin-Chieh
Chu, Ching-Liang
Chen, Der-Yuan
Lin, Chi-Chen
關鍵字: Citrus
Contact hypersensitivity (CHS)
Dendritic cells
Peels
T cells
Animals
Bone Marrow Cells
Cell Differentiation
Cells, Cultured
Cytokines
Dendritic Cells
Dermatitis, Allergic Contact
Dinitrofluorobenzene
Female
Haptens
Immunologic Factors
Lipopolysaccharides
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases
NF-kappa B
Phagocytosis
Phytotherapy
Plant Preparations
T-Lymphocytes
Citrus
摘要: It has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4(+) and CD8(+) T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC.
URI: http://hdl.handle.net/11455/86426
ISSN: 1878-1705
Appears in Collections:生物醫學研究所

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