Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/86426
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dc.contributor.authorLi, Shimingzh_TW
dc.contributor.authorLin, Yi-Chinzh_TW
dc.contributor.authorHo, Chi-Tangzh_TW
dc.contributor.authorLin, Ping-Yizh_TW
dc.contributor.authorSuzawa, Michikozh_TW
dc.contributor.authorWang, Hsin-Chiehzh_TW
dc.contributor.authorChu, Ching-Liangzh_TW
dc.contributor.authorChen, Der-Yuanzh_TW
dc.contributor.authorLin, Chi-Chenzh_TW
dc.date2014-05-
dc.date.accessioned2015-08-04T03:32:43Z-
dc.date.available2015-08-04T03:32:43Z-
dc.identifier.issn1878-1705zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/86426-
dc.description.abstractIt has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4(+) and CD8(+) T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC.zh_TW
dc.language.isoenzh_TW
dc.relationInternational immunopharmacology, Volume 20, Issue 1, Page(s) 12-23.zh_TW
dc.subjectCitruszh_TW
dc.subjectContact hypersensitivity (CHS)zh_TW
dc.subjectDendritic cellszh_TW
dc.subjectPeelszh_TW
dc.subjectT cellszh_TW
dc.subjectAnimalszh_TW
dc.subjectBone Marrow Cellszh_TW
dc.subjectCell Differentiationzh_TW
dc.subjectCells, Culturedzh_TW
dc.subjectCytokineszh_TW
dc.subjectDendritic Cellszh_TW
dc.subjectDermatitis, Allergic Contactzh_TW
dc.subjectDinitrofluorobenzenezh_TW
dc.subjectFemalezh_TW
dc.subjectHaptenszh_TW
dc.subjectImmunologic Factorszh_TW
dc.subjectLipopolysaccharideszh_TW
dc.subjectMice, Inbred C57BLzh_TW
dc.subjectMitogen-Activated Protein Kinaseszh_TW
dc.subjectNF-kappa Bzh_TW
dc.subjectPhagocytosiszh_TW
dc.subjectPhytotherapyzh_TW
dc.subjectPlant Preparationszh_TW
dc.subjectT-Lymphocyteszh_TW
dc.subjectCitruszh_TW
dc.titleFormulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivityzh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.intimp.2014.02.005zh_TW
Appears in Collections:生物醫學研究所
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