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標題: Rice bran feruloylated oligosaccharides activate dendritic cells via Toll-like receptor 2 and 4 signaling
作者: Lin, Chi Chen
Chen, Hua Han
Chen, Yu Kuo
Chang, Hung Chia
Lin, Ping Yi
Pan, I-Hong
Chen, Der-Yuan
Chen, Chuan Mu
Lin, Su Yi
關鍵字: Animals
Antigens, CD40
Antigens, CD80
Bone Marrow Cells
Cell Differentiation
Coumaric Acids
Dendritic Cells
Extracellular Signal-Regulated MAP Kinases
Gene Expression Regulation
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Immunologic Factors
MAP Kinase Kinase 4
Mice, Inbred C3H
Mice, Inbred C57BL
NF-kappa B
Oryza sativa
Signal Transduction
Toll-Like Receptor 2
Toll-Like Receptor 4
p38 Mitogen-Activated Protein Kinases
摘要: This work presents the effects of feruloylated oligosaccharides (FOs) of rice bran on murine bone marrow-derived dendritic cells (BMDCs) and the potential pathway through which the effects are mediated. We found that FOs induced phenotypic maturation of DCs, as shown by the increased expression of CD40, CD80/CD86 and MHC-I/II molecules. FOs efficiently induced maturation of DCs generated from C3H/HeN or C57BL/6 mice with normal toll-like receptor 4 (TLR-4) or TLR-2 but not DCs from mice with mutated TLR4 or TLR2. The mechanism of action of FOs may be mediated by increased phosphorylation of ERK, p38 and JNK mitogen-activated protein kinase (MAPKs) and increased NF-kB activity, which are important signaling molecules downstream of TLR-4 and TLR-2. These data suggest that FOs induce DCs maturation through TLR-4 and/or TLR-2 and that FOs might have potential efficacy against tumor or virus infection or represent a candidate-adjuvant approach for application in immunotherapy and vaccination.
ISSN: 1420-3049
Appears in Collections:生物醫學研究所



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