Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/90127
標題: Study on the Effect of Fungicide Mixtures on Microbial Toxicity
混合農藥對微生物毒效之影響研究
作者: Yun-Hsi Hsieh
謝昀羲
關鍵字: no
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摘要: Agriculture is an important industry for people, with advances in technology and medicine, the ways of agricultural production have gradually changed. People use pesticides to avoid pests and diseases from crops. However, the excessive use of pesticides let people began thinking whether pesticides cause negative impact on people and environment, especially the toxicity of mixtures, it's the focus of many studies. Carbendazim, procymidone and triforine are fungicide that commonly used on agricultural. Caffeic acid and cinnamic acid are commonly found soil rhizosphere phenolic compounds. This five pesticides above are common found in our life, but we know little about their single and mixture toxicity. So in this study, we discuss carbend- azim, procymidone, triforine, caffeic acid and cinnamic acid single and mixture toxicity by botrytis cinerea and Micrtox antimicrobial test. Further use UV spectrophotometer to compare single and mixture absorption spectra. Trying to find out if structure change after pesticides mix. Attempt to identify and determine the parameters of the experimental toxicity data then predict the toxicity of linear equations. Finally, using Autodock Tools to simulate bacteria and pesticides relationship between combine position, toxicity and binding energy. Results show that carbendazim mix with triforine will produce antagonism leads to reduced toxicity.
農業生產一直是人類賴以生存的產業,隨著科技及醫學的進步,人們對於農業生產的方式也逐漸改變。人們使用農藥來確保作物不受病蟲害影響而降低產量。然而農藥過度使用的結果,卻也讓人們開始反思農藥對人們及環境是否會帶來負面的影響,尤其是農藥混合之後的毒性,更是目前許多研究的重點。貝芬替、撲滅寧、賽福寧是農業上常用的殺菌劑,而咖啡酸及肉桂酸則是根圈土壤中常見的酚酸化合物。以上五種農藥皆是日常生活中常見的常接觸的化合物,然而我們對其單一或混合毒性的了解卻所知甚少。因此在本研究中,分別利用灰黴菌及 Microtox 發光菌之抑菌實驗討論了貝芬替、撲滅寧、賽福寧、咖啡酸及肉桂酸單一及混合的毒性。使用紫外線可見光光譜儀觀察單一及混合的吸收光譜的差異,希望可以得到農藥混合之後是否會有結構上的改變。嘗試藉由定量構效關係(Quantitativestructure-activity relantionship , QSAR)電子參數的角度,能夠找出決定毒性的參數與實驗值毒性數據線性關係之毒性預測方程式。最後使用Autodock Tools 嘗試模擬發光菌與農藥結合的情況,期望可以得知農藥在發光菌上結合位置和能量與毒性的關係。從結果中可以得知貝芬替混合賽福寧後會產生拮抗作用導致毒性降低。
URI: http://hdl.handle.net/11455/90127
文章公開時間: 10000-01-01
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