請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/90629
標題: 1. Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Thiols with Aryl Iodides in Water 2. Copper-Catalyzed Cross-Coupling Reaction of Formamides with Thiols
1. 微波促進水相銅金屬催化碳一硫鍵交互耦合反應 2. 銅金屬催化甲醯胺衍生物與硫醇之交互耦合反應
作者: 陳怡安
Yi-An Chen
關鍵字: no
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摘要: The first part of this thesis, the microwave-promoted formation of C-S bond through the coupling of thiols with aryl iodides is reported. A combination of copper salt with 1,10-phenanthroline can serve as an active catalyst for this reaction. A variety of aryl iodides reacted smoothly with thiols to provide the corresponding aryl thioethers in good to excellent yields. It is important to note that the reactions were performed in water, with a short reaction time (30 min). In the second part of this thesis, we report that copper salt can be used as a catalyst for the coupling reaction of thiols with formamides in the presence of TBHP as an oxidant.
本論文的第一部分介紹微波促進芳香基鹵化物與硫醇之碳一硫鍵生 成耦合反應。在銅金屬和配體的幫助下可以有效進行碳一硫鍵生成反應。 值得一提的是,此反應在水相中進行,且反應時間只需 30 分鐘。論文的第二部分我們利用便宜、低毒性的氧化銅作為催化劑,過氧 化叔丁醇作為氧化劑,活化甲醯安的碳一氫鍵,進而與硫醇進行碳一硫鍵生成反應。
URI: http://hdl.handle.net/11455/90629
文章公開時間: 10000-01-01
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