請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/90645
標題: Synthesis of Ganglioside Hp-s1 and Its Phytosphingosine Modified Analogues
合成醣苷神經鞘胺脂質Hp-s1及其在植物神經鞘胺醇上修飾碳鏈之衍生物
作者: 廖盈茹
Ying-Ju Liao
關鍵字: ganglioside Hp-s1
analogues of ganglioside Hp-s1
醣苷神經鞘胺脂質
醣苷神經鞘胺脂質衍生物
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摘要: Ganglioside Hp-s1 1, which was isolated from the ovary of sea urchin Diadema setosum, displays great neuritogenic activity. It is difficut to get enough quantity for research from nature. Hence, the total synthsis of ganglioside Hp-s1 1 and its phytosphingosine modified analogues is the goal of this thesis. Staring with D-lyxose, glucose and sialic acid furnishes three desired building blocks. After two glycosylation reactions that affod an αβ-linked disaccharide, amidization and global deprotection, ganglioside Hp-s1 1 and its derivative were obtained.
Hp-s1 1是一種具有神經再生活性之醣苷神經鞘胺酯質,主要由刺冠海膽的卵巢中所分離而得。但由天然物中取得不易,導致不利於研究。因此,合成醣苷神經鞘胺酯質Hp-s1 1及其在植物神經鞘胺醇上做修飾之衍生物為本篇論文宗旨。首先,由D-來蘇醣、葡萄醣和唾液酸為起始物,分別經由六步驟、三步驟和七步驟可合成出三種建構基石。接著再進行兩次的醣鏈結反應,建構出ab-醣苷的雙醣醣脂質型態。最後,進行醯胺鍵的生成和去除所有保護基,即可得Hp-s1 1及其衍生物。
URI: http://hdl.handle.net/11455/90645
文章公開時間: 2016-08-31
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