Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/90651
標題: 1.DTBP-Promoted Synthesis of Thioesters from Aldehydes and Thiols 2. Copper-Catalyzed Amide Synthesis from Aldehydes and Amines in Water
1.二叔丁基過氧化物促進醛類與硫醇生成硫酯之反應 2.水相銅催化醛類與胺類生成醯胺之反應
作者: 呂紹億
Shao-Yi Lu
關鍵字: thioester
amide
硫醇
醯胺
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摘要: First part of this thesis discusses the formation of C-S bond in the presence of DTBP as an oxidant under metal-free and solvent-free conditions. This system shows good functional group compatibility with electron donating and electron withdrawing groups. Halo-groups are also well tolerated under reaction conditions employed. The heterocyclic starting materials also utilized for this reaction system. Second part of this thesis describes the copper-catalyzed direct oxidative cross-coupling of aldehydes with amines to afford amides in the presence of TBHP as an oxidant. Interestingly, our catalytic system is useful for coupling of both aliphatic and aromatic aldehydes with amines, providing the corresponding amides in good to excellent yields.
本論文的第一部分,我們利用二叔丁基過氧化物(DTBP)作為氧化劑在無金屬、無溶劑的條件下進行碳-硫鍵的生成反應,此系統官能基容忍性非常高,不論是推電子基或強拉電子基以及含有鹵素官能基都可容忍在此條件反應,並且提升雜環起始物的反應性。 本論文的第二部分,我們發展出一個簡便的方法,利用銅金屬催化醛類與胺類化合物通過以過氧化叔丁醇(TBHP)作為氧化劑的條件下進行醯胺化反應。值得注意的是,芳香基醛類與烷基醛類對於胺類化合物皆能順利在此系統下進行反應,且都有不錯的產率。
URI: http://hdl.handle.net/11455/90651
文章公開時間: 2017-08-13
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