Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/90684
標題: 1. Syntheses of α-Thio-β-dicarbonyl Compounds through Oxidative Coupling Reaction 2. Microwave-Assisted Oxidative Cross-Coupling Reaction of Aldehydes with Thiols
1.通過氧化耦合反應合成α-硫基-β-雙羰基化合物 2.微波促進醛類與硫醇之交互耦合反應
作者: 劉奕緯
Yi-Wei Liu
關鍵字: Oxidative
Microwave
Aldehydes
Thiols
氧化
微波
醛類
硫醇
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摘要: K2S2O8/I2 promoted C-S coupling reaction of β-diketone with disulfide has been described. The resulting α-thio-β-diketones compounds were obtained in good to excellent yields. Both diaryl and dialkyl disulfides are coupled well with a variety of β-diketones under metal-free and solvent-free conditions. A very simple microwave-promoted synthesis of thioesters through the coupling of thiols and aldehydes under metal-free and solvent-free conditions was reported. This system shows good functional group tolerance, functional groups including bromo, iodo, nitrile, trifluoromethyl, thiophene and pyridine are all tolerated under the reaction conditions employed. Both aryl and alkyl thiols are coupled smoothly with a broad spectrum of aldehydes to afford the corresponding thioesters in good to excellent yields.
我們利用過硫酸鉀搭配碘促進β-雙酮與二硫化物進行碳-硫鍵耦合反應,成功得到α-硫基-β-雙羰基化合物且有不錯至很好的產率。不論是芳香基或是烷基的二硫化物都可以和不同的β-雙酮在無金屬及溶劑的條件下進行反應。 本研究利用微波在無金屬及溶劑的條件下促進碳-硫鍵耦合反應,此系統只需要15分鐘的反應時間,而且對官能基的容忍度非常好,不論是推電子基或拉電子基都可以進行反應。
URI: http://hdl.handle.net/11455/90684
文章公開時間: 2018-08-13
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