Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/92614
標題: 第二型糖尿病患者合併內頸動脈狹窄的心血管危險因子探討
Cardiovascular risk factors of internal carotid artery stenosis in type II diabetes
作者: 林曉菁
Hsiao-Ching Lin
關鍵字: 第二型糖尿病
內頸動脈狹窄
脂蛋白(a)
高敏感性C-反應蛋白
type II diabetes mellitus
internal carotid artery stenosis
lipoprotein(a)
high-sensitivity C-reactive protein
引用: 中文參考文獻 何柏陵。2010。淺談頸動脈狹窄。高醫醫訊月刊。30(4):15-16。 徐嘉吟、方信智。2006。心血管疾病的新指標-高敏感性C-反應蛋白(hs-CRP)。基層醫學。21(3):63-67。 翁文章。1999。腦血管疾病及超音波,第一版。學藝軒圖書出版社。 莊立民、蘇玲華等。2006。糖尿病健康生活指南,第一版。健康文化出版。 郭達霖、吳至行。2003。飲酒與第二型糖尿病發生率的關係。台灣醫界。46(3):27-29。 陳志弘。2007。糖尿病與中風。台灣腦中風學會電子報。14(4):32-34。 陳淑珍、趙麗淑、陳虹珍、吳宇暉。2009。D-Dimer在早期診斷心肌梗塞病患上之應用。臺灣醫檢會報。24(2):44-49。 黃中洋。簡介血液中膽固醇以外的心血管疾病危險因子。2010。藥學雜誌。26(1):33-38。 西文參考文獻 American Heart Association (AHA). 2003. Heart Disease and Stroke Statistics – 2004. Update. Dallas. Bayes-Genis, A., J. Mateo, M. Santaló, A. Oliver, J. Guindo, L. Badimon, et al. 2000. D-Dimer is an early diagnostic marker of coronary ischemia in patients with chest pain. Am Heart J. 140(3):379-84. Belsky, M., D. Gaitini, D. Goldsher, A. Hoffman, and M. Daitzchman. 2000. Color-coded duplex ultrasound compared to CT angiography for detection and quantification of carotid artery stenosis. Eur J Ultrasound. 12(1):49-60. Berger, K., H. Schulte, F. Stögbauer, and G. Assmann. 1998. Incidence and risk factors for stroke in an occupational cohort: the PROCAM Study. Prospective Cardiovascular Muenster Study. Stroke. 29(8):1562-6. Bonita, R. 1986. Cigarette smoking, hypertension and the risk of subarachnoid hemorrhage: A population-based case-control study. Stroke. 17(5):831-35. Chobanian, A. V., G. L. Bakris, H. R.Black, W. C. Cushman, L. A. Green, J. L. Izzo, et al. 2003. The Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA. 289(19):2560-71. Chong, P. H. and B. S. Bachenheimer. 2000. Current, new and future treatments in dyslipidaemia and atherosclerosis. Drugs. 60(1):55-93. Chuang, L., S. Tsai, J. Juang, W. Tsai, and T. Tai. 2000. Genetic epidemiology of type 1 diabetes mellitus in Taiwan. Diabetes Res Clin Pract. 50(Supp 2):S41-7. Creager, M. A., T. F. Luscher, F. Cosentino, and J. A. Beckman. 2003. Diabetes and vascular disease. pathophysiology, clinical consequences, and medical therapy: Part I. Circulation.108:1527-32. Creager, M. A., V. J. Dazu, and J. L. Loscalzo. 2006. Vascular medicine: A companion to Braunwald's heart disease. Philadelphia : Elsevier. D'Agostino, R. B., S. Grundy, L. M. Sullivan, and P. Wilson. 2001. Validation of the Framingham coronary heart disease prediction scores. Results of a multiple ethnic groups investigation. JAMA. 286(2):180-7. D'Agostino, R. S., L. G. Svensson, D. J. Neumann, H. H. Balkhy, W. A. Williamson, and D. M. Shahian. 1996. Screening carotid ultrasonography and risk factors for stroke in coronary artery surgery patients. Ann Thorac Surg. 62:1714-23. Davis, N. E. 2005. Atherosclerosis-An Inflammatory Process. J Insur Med. 37:72-5. Erqou, S., S. Kaptoge, P. L. Perry, A. Thompson, I. R. White, S. M. Marcovina, et al. 2009. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. 302(4):412-23. Erren, M., H. Reinecke, R. Junker, M. Fobker, H. Schulte, J. O. Schurek, et al. 1999. Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral arteries. Arterioscler Thromb Vasc Biol. 19(10):2355-63. Foody, J. M. 2001. Preventive Cardiology: Strategies for the Prevention and Treatment of Coronary Artery Disease. New Jersey: Humana press. Gorelick, P. B., K. S. Wong, H. J. Bae, and D. K. Pandey. 2008. Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier. Stroke. 39(8):2396-9. Grant, E. G., C. B. Benson, G. L. Moneta, A. V. Alexandrov, J. D. Baker, E. I. Bluth, et al. 2003. Carotid artery stenosis: Gray-scale and Doppler US diagnosis-society of radiologists in ultrasound consensus conference. Radiology. 229:340-6. Grundy, S. M., J. I. Cleeman, C. N. Merz, H. B. Jr Brewer, L. T. Clark, D. B. Hunninghake, et al. 2004. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel Ⅲ guidelines. Circulation. 110(2):227-39. He, J., M. J. Klag, Z. Wu, and P. K. Whelton. 1995. Stroke in the People's Republic of China. II. Meta-analysis of hypertension and risk of stroke. Stroke. 26(12):2228-32. Kissela, B. M., J. Khoury, D. Kleindorfer, D. Woo, A. Schneider, K. Alwell, R. et al. 2005. Epidemiology of ischemic stroke in patients with diabetes: the Greater Cincinnati/Northern Kentucky Stroke Study. Diabetes Care. 28:355-9. Kim, B. S., H.S. Jung, O.Y. Bang, C.S. Chung, K.H. Lee, and G.M. Kim. Elevated serum lipoprotein(a) as a potential predictor for combined intracranial and extracranial artery stenosis in patients with ischemic stroke. 2010. Atherosclerosis. 212(2):682-8. Klein, J. H., R. A. Hegele, D. G. Hackam, M. L. Koschinsky, M. W. Huff, and J. D. Spence. 2008. Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area. Arterioscler Thromb Vasc Biol. 28:1851-6. Kofoed, S.C., H.H. Wittrup, H. Sillesen, B.G. Nordestgaard. 2003. Fibrinogen predicts ischaemic stroke and advanced atherosclerosis but not cholucent, rupture-prone carotid plaques. The Copenhagen City Heart Study. Eur Heart J. 24:567-76. Koschinsky, M. L. 2004. Lipoprotein(a) and the link between atherosclerosis and thrombosis. Can J Cardiol. 20(Suppl B):37B-43B. Liapis, C., J. Kakisis, V. Papavassiliou, C. Tsoukala, T. Makris, E. Kaperonis, et al. 2004. Hemostatic function and carotid artery disease. Int Angiol. 23(1):14-7. Lin, K. P., S. Y. Kwan, S. Y. Chen, S. S. Chen, K. B. Yeung, L. G. Chia, et al. 1993. General neuropathy in Taiwan: an etiologic survey. Neuroepidemiology. 12(5):257-61. Meigs, J. B., D. E. Singer, L. M. Sullivan, K. A. Dukes, R. B. D'Agostino, D. M. Nathan, et al. 1997. Metabolic control and prevalent cardiovascular disease in non-insulin-dependent diabetes mellitus (NIDDM): The NIDDM Patient Outcome Research Team. Am J Med. 102(1):38-47. Ng, M. K., C. M. Quinn, J. A. McCrohon, S. Nakhla, W. Jessup, D. J. Handelsman, et al. 2003. Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis. J Am Coll Cardiol. 42:1306-13. Panzram,G. 1987. Mortality and survival in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 30(3):123-31. Patel, V. B., M. A. Robbins, and E. J. Topol. 2001. C-Reactive Protein: A 'Golden Marker' for inflammation and coronary artery disease. Cleve Clin J Med. 68(6):521-4. Petersen, N. H., A. B. Schmied, J. A. Zeller, H. Plendl, G. Deuschl, and P. Zunker. 2007. Lp(a) Lipoprotein and plasminogen activity in patients with different etiology of ischemic stroke. Cerebrovasc Dis. 23(2-3):188-93. Rainwater, D. L. and C. M. Kammerer. 1998. Lipoprotein Lp(a): effects of allelic variation at the LPA locus. J Exp Zool. 282(1-2):54-61. Ridker P. M., C. H. Hennekens, J. E. Buring, and N. Rifai. 2000. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N En J Med. 342(12):836-43. Ridker, P. M., J. E. Buring, J. Shih, M. Matias, and C. H. Hennekens. 1998. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation. 98:731-3. Rosamond, W., K. Flegal, K. Furie, A. Go, K. Greenlund, N. Haase, et al. 2008. Heart disease and stroke statistics-2008 update: a report from the American Heart Association statistics committee and stroke statistics subcommittee. Circulation. 117:e25-e146. Saba L., R. Sanfilippo, R. Pirisi, L. Pascalis, R. Montisci and G. Mallarini. Multidetector-row CT angiography in the study of atherosclerotic carotid arteries. 2007. Neuroradiology. 49:623-37. Sadanaga, T., M. Sadanaga, and S. Ogawa. 2010. Evidence that D-dimer levels predict subsequent thromboembolic and cardiovascular events in patients with atrial fibrillation during oral anticoagulant therapy. J Am Coll Cardiol. 55(20):2225-31. Salomaa, V., V. Stinson, J. D. Kark, A. R. Folsom, C. E. Davis, and K. K. Wu. 1995. Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Circulation. 91:284-90. Scanu, A. M. 2003. Lipoprotein(a) and the atherothrombotic process: mechanistic insights and clinical implications. Curr Atheroscler Rep. 5(2):106-13. Semenkovich, C. F. and J. W. Heinecke. 1997. The mystery of diabetes and atherosclerosis: time for a new plot. Diabetes. 46(3):327-34. Shah, P.K. 1997. Plaque disruption and thrombosis: potential role of inflammation and infection. Cardiol Clin. 1999 17(2):271-81. Shinton, R. and G. Beevers. 1989. Meta-analysis of relation between cigarette smoking and stroke. Br Med J. 298(6676):789-94. Su, T. C., J. S Jeng, K. L Chien, F. C. Sung, H. C.Hsu, and Y. T. Lee. 2001. Hypertension status is the major determinant of carotid atherosclerosis: a community-based study in Taiwan. Stroke. 32(10):2265-71. Sutton-Tyrrell, K., H. G. Alcorn, S. K. Wolfson, S. F. Kelsey, and L. H. Kuller. 1993. Predictors of carotid stenosis in older adults with and without isolated systolic hypertension. Stroke. 24:355-61. Tai, T. Y., C. L. Yang, C. J. Chang, S. M. Chang, Y. H. Chen, B. J. Lin, et al. 1987. Epidemiology of diabetes mellitus among adults in Taiwan. J Med Assoc Thai. 70(supple 2):42-8. Tanimoto, S., Y. Ikari, K. Tanabe, S. Yachi, H. Nakajima, T. Nakayama, et al. 2005. Prevalence of carotid artery stenosis in patients with coronary artery disease in Japanese population. Stroke. 36:2094-8. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. 2002. Circulation. 106(25):3143-421. Wannamethee, S. G., A. G. Shaper, and I. J. Perry. 1997. Serum Creatinine Concentration and risk of cardiovascular disease: A possible marker for increased risk of stroke. Stroke. 28:557-63. Weerd, M.D., J. P. Greving, A. W. F. de Jong, E. Buskens, and M. L. Bots. 2009. Prevalence of asymptomatic carotid artery stenosis according to age and sex. Systematic review and metaregression analysis. Stroke. 40:1105-13. Wolf, P.A. 1986. Cigarettes, alcohol, and stroke. N Engl J Med. 315(17):1087-89. Zhou, D., P. Y. Yang, B. Zhou, and Y. C. Rui. 2007. Fibrin D-dimer fragments enhance inflammatory responses in macrophages: role in advancing atherosclerosis. Clin Exp Pharmacol Physiol. 34(3):185-90.
摘要: 背景 頸動脈狹窄為導致第二型糖尿病患者腦缺血的重要因素。已有研究指出頸動脈狹窄與缺血性腦中風有關聯性,被認為是評估腦血管疾病風險的有用指標。因此,預測糖尿病患者是否會引發腦梗塞具有重要的臨床意義。 目的 本研究探討第二型糖尿病患者合併內頸動脈狹窄的相關危險因子,以期達到預防糖尿病患者腦中風發生的機會。 方法 本研究為橫斷性研究,共收集83位第二型糖尿病患者,其中有53位男性,30位女性,平均年齡為66.2 ± 6.3歲。所有患者均須接受顱外超音波檢測以確認是否有內頸動脈狹窄的情形。血液檢體測定包含血脂肪、凝血功能、纖維溶解功能及發炎參數等項目,並記錄心血管相關危險因子,包括高血壓、糖尿病、血脂異常、肥胖、抽菸、喝酒及運動情況。統計分析採用卡方檢定、獨立樣本t檢定及多元邏輯斯迴歸分析法。 結果 內頸動脈狹窄的盛行率有28.9%(24例)。脂蛋白(a) (OR= 3.147,95% CI:1.134-8.739,P=0.028)及高敏感性C-反應蛋白(OR= 2.511,95% CI:1.022-6.168,P=0.045)為內頸動脈狹窄的獨立預測因子。 結論 血中脂蛋白(a)與高敏感性C-反應蛋白濃度上升會增加第二型糖尿病患者發生內頸動脈狹窄的風險。
Background Carotid artery stenosis is an important cause of cerebral ischemia for patients with type II diabetes mellitus (DM). Carotid artery stenosis might induce ischemic stroke. It have been recognized as an useful tool to assess the risk of cerebrovascular diseases. Therefore, identifying the potential of developing cerebral infarction is clinically important for DM patients. Objective Present study investigated the cardiovascular related risk factors in type II DM. Methods This cross sectional study recruited 83 patients with type II DM. There were 53 men and 30 women. Their mean age was 66.2 ± 6.3 years. All patients underwent extracranial color-coded duplex sonography. We measured their lipid profile, coagulation, fibrinolytic and inflammation parameters. Cardiovascular risk factors including hypertension, diabetes mellitus, dyslipidemia, obesity, smoking, alcohol and physical activity were evaluated. Test statistics included the chi-spuare test, independent t test, and multiple logistic regression. Results 28.9% (n=24) of patients had internal carotid artery stenosis. Lipoprotein(a) (OR= 3.147, 95% CI:1.134-8.739, P=0.028) and high-sensitivity C-reactive protein (OR= 2.511, 95% CI:1.022-6.168, P=0.045) were the independent predictor for internal carotid artery stenosis. Conclusions Elevated Lp(a) and hs-CRP increased the risk of internal carotid artery stenosis in type II DM subjects.
URI: http://hdl.handle.net/11455/92614
其他識別: U0005-2301201401193500
文章公開時間: 10000-01-01
Appears in Collections:生命科學院碩士在職專班

文件中的檔案:

取得全文請前往華藝線上圖書館

Show full item record
 
TAIR Related Article
 
Citations:


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.