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|標題:||Effects of two low doses of prostaglandin F2α on luteolysis in dairy cows|
兩次低劑量prostaglandin F2α 對於乳牛黃體降解的效果
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|摘要:||具有黃體降解效果的prostaglandin F2α (PGF2α)在世界各地被廣泛使用，根據研究指出有7-20%牛隻在使用標準劑量PGF 2α時會出現黃體部分降解的現象。近年來以連續或多次等方式註解PGF 2α的研究，證明多次注射PGF 2α較傳統的單一次注射更能夠成功降解黃體，因此，本實驗研究目的為觀察並比較乳牛間隔24小時注射兩劑低劑量PGF 2α與標準劑量PGF 2α在黃體降解效果上的差異。實驗採用27隻荷氏登泌乳牛，於動情週期第9~12天，以超音波掃描確認卵巢左或右側至少有一個最長軸距大於2.5公分之黃體方開始進行實驗。實驗牛隻隨機分為四組：Group 1於實驗開始肌肉注射375 µg PGF 2α(Estrumate_R, cloprostenol sodium)，並於24小時候在注射250 µg PGF 2α；Group 2 與Group 1相同，但第二劑改為2mL生理食鹽水注射液；Group 3注射500 µg PGF 2α(標準劑量)；Group 4注射2mL 生理食鹽水注射液做為對照組。於實驗開始前及注射PGF 2a 或生理食鹽水後每24小時以超音波掃描卵巢及採血檢驗血清P4濃度。結果顯示，Group 1、2、3在注射藥物後的1-4天與對照組Group4於黃體面積與血清P4濃度上街出現顯著性差異(p<0.05)。黃體面積變化顯示，Group1與2的牛隻黃體面積於注射藥物後第2及3天出現顯著性差異。血清P4濃度結果中，注射藥物的三個組別間雖未達顯著性差異，但只有注射兩劑的Group1的血清P4濃度持續下降，全數牛隻於注射藥物後第3天皆低於1 ng/mL。所有組別只有Group1於實驗開始五天內所有牛隻黃體(100%)完全降解，且87.5%牛隻(7/8)於黃體降解後排卵，相較於Group2的66.7%(4/6)黃體降解率、0%排卵率及Group3的62.5%(5/8)黃體降解率、62.5%(5/8)排卵率，Group1有較佳的黃體完全降解率及排卵率。總結來說，連續注射兩次低劑量PGF 2a相較於標準劑量有較穩定且較高比例的黃體完全降解效果，進而出現較高比例的牛隻於五天內排卵。|
The luteolytic agent, prostaglandin F2α(PGF2α), has been used extensively to manipulate estrous cycle in cattle, while partial luteolysis had been reported as a main problem of administrating PGF2α. Sequential administrations of PGF2α resulted in increased luteolytic efficacy had been reported. Therefore, the objective of the present study was to evaluate the effect of repeated administration of PGF2α at interval of 24 hrs on luteolysis comparing to standard dosage in dairy cows. Twenty-seven cows at the middle stage of estrus cycle (day 9~12) with a corpus luteum (CL)≧2 cm diameter were randomly allocated to receive cloprostenol (day 0) as follows:375 µg (1.5mL) on day 0, followed by 250 µg (1 mL) im (Group 1) or 1 mL of saline (Group 2) 24 hours after the first injection, 500ug (2mL) (Group 3) or 2 mL of saline as control (Group 4). The ovaries of each cow were scanned by transrectal ultrasonography daily for 6 days, while serum progesterone (P4) concentrations were analyzed. The results indicated that Group 1, 2 and 3 showed significant difference (p<0.05) in terms of reduction in the area of CL and P4 concentrationin compating to Group 4 from day 1 to 4. A significant difference was demonstrated between Group 1 and 2 in CL area from day 2 to 3, however, consistent regression in CL area and declination of P4 were only noted in Group 1. Complete luteolysis occurred in all cows in Group 1, while partial luteolysis was observed in 2/6 and 3/8 cows in Group 2 and 3, respectively. Ovulation rate was also higher in Group 1 comparing to the other groups (87.5% vs 0% and 62.5%). In conclusion, administration of two low doses of PGF__ had more beneficial effect on consistent regression of CL resulting in subsequent ovulation than those of using single dose.
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