Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/93023
標題: Studies on the pharmacokinetics and residues of oxytetracycline used in Chinese soft-shell turtle, Pelodiscus sinensis, at low temperature
在低溫環境下土黴素在中華鱉之藥物動力學及殘留研究
作者: Shih-Ying Huang
黃世穎
關鍵字: 土黴素
中華鱉
藥物殘留
oxytetracycline
HPLC
soft shell fish
引用: 參考文獻 日本厚生勞動省。2014。 http://www.m5.ws001.squarestart.ne.jp/foundation/search.html 台灣財政部關務署統計資料庫。2013。 https://portal.sw.nat.gov.tw/APGA/GA01 Codex Alimentarius Commission, 2012. http://www.codexalimentarius.net/mrls/pestdes/jsp/pest_q-e.jsp European Food Safety Authority, EFSA, 2008. http://www.ema.europa.eu/ema/ 丁梨慧,邵雙良,任一平,2006。液相色譜-電噴霧串聯四極杆質譜法檢測牛奶中磺胺類抗生素的殘留。第 11 屆全國離子色譜學術報告會論文集。 王光榮,毛紅斌,1998.。山西野生鱉資源調查評估與保護。自然資源學。13,187-191。 那琦,謝文全,1977。重輯名醫別錄。中國醫藥學院中國藥學硏究所。 李秀珍,孟慶法,2003。紫外分光光度法測定土黴素片的含量。中國藥品標準。4;6,24。 周劍光,楊先樂,1999。中華鱉癤瘡,紅脖子、赤斑病併發症的病原研究。水產學報。23,270-277。 周懷悟,沈佳慶,1992。匹洛西卡在家兔體內的腸肝循環藥物動力學分析。中國藥理學報。2:180-182。 周進,黃捷,宋曉玲。2003。水產動物藥物代謝動力學研究概況。海水健康養殖的理論與實踐。419-428。 周輝明,張愛芳,吳志強,2009。兩種抗生素在甲魚組織中的殘留研究。 江西水產科技。23-26。 周志明,尹文林,沈錦玉,潘曉藝,顧志敏,曹錚,朱俊傑,2013。抗水黴菌藥物的篩選、研製及其防治作用。安徽農業科學。41, 7849-7851。 馬越鳴,孫瑞元,1987。藥物C-T曲線的雙峰現象。國外醫學。藥學分冊。3:168。 胡超群,吳後波,1995。中華鱉水黴病 (白斑病) 的病原及防治研究。南海研究與開發。70-73。 胡超群,吳後波,1995。中華鱉腐皮病致病菌的研究。南海研究與開發。 74-77。 胡太文,羅祖國,1997。肉兔土黴素中毒的診治。雲南畜牧獸醫。43-43。 吳惠仙,王淑霞,李行先,周向陽,王建華,唐寶華,1998。中華鱉產氣單胞菌癤瘡病的研究。東海海洋。16,40-46。 吳涓,黃蓓琳,王洪泉。2002。EXCEL在溶出度實驗資料處理中的應用。藥學服務與研究。2:311-313。 吳惠仙,薛俊增,2004。中華鱉腐皮病的病理組織學研究。浙江大學學報 (理學版) 。31,451-455。 張留,陸彬,黃建,楊為民,1990。微型膠囊劑在動物體內的藥物動力學模型。生物數學學報,1:16-20。 張奇亞,李正秋,江育林,梁紹昌,桂建芳,1996。中華鱉病毒病原的發現。科學通報。41,1987-1990。 張繼穩,斐小兵。2004。殘數法計算單室模型藥物血管外多劑量給藥的吸收和清除動力學參數。安徽醫科大學學報。 39(1):34。 徐曉娣,孫輝輝,榮蓉,溫冰,張向榮,何仲貴,2008。複方軟膠囊中齊敦果酸 (Oleanolic acid) 在大鼠體內的藥物動力學及相對生物利用度。中國藥劑學雜誌。6:392-399。 章開訓、金小軍,1993。水溫對鱉心律的影響。特產研究,2:19-20。 崔青曼,張躍紅,1998。中華鱉腐皮病病原菌及防治藥物研究。水利漁業,13-14。 袁進,石磊,趙樹進。2008。基於Excel函數求解血管外給藥二室模型的藥動學及隔室模型參數。中國藥房。 19(2):106-108。 陳亭亭潘日南,2009。濫用藥物的檢驗分析及認證制度。臺灣警察專科學校警專學報。4,35-46。 陳俊宏,2011。台灣中華鱉繁殖產業經濟效益分析。 湯崢嶸,王道尊,1998。中華鱉生化組成的分析:肌肉氨基酸的組成。 水生生物學報。22,307-313。 葉普仁,1996。鱉鰓腺炎病及治療。淡水漁業。26,42-43。 葉鳴,蘇銀法。2005。Excel規劃求解法計算靜脈注射給藥的藥動學參數.中國藥師,14(8):744-746. 黃曉紅,2005。雞土黴素中毒的診斷。福建農業。25-25。 楊燕忠,1997。幾種藥物對中華鱉稚鱉的毒性試驗。水產科技,24-26。 溫源鏜,2010。生技保健食品製程最佳化之研究-甲魚精製程為例。國立高雄第一科技大學。 楊萍,唐業忠,王躍招,2011。中國鱉屬的分類歷史簡述。 虞蘊如,儲衛華,李克敏,2004。中華鱉紅脖子、紅底板病的病原分離鑒定。動物醫學進展。25,102-105。 廖治清,2005。超量投餵土黴素致家兔中毒的診治。獸藥與飼料添加劑。10,40-40。 薛紅玲,2000。中華鱉腐皮病防治的研究。淡水漁業。30,33-35。 譚北平,1996。中華鱉腐皮病及防治方法研究。水利漁業,26-27。 羅忠芬,廖時權,1996。中華鱉常見病綜合防治技術。小康生活。7:38-39 羅方興,毛盼,王榮華,曾丹,肖調義,鐘蕾,2013。中華鱉腐皮病的病原鑒定與藥敏試驗。水生態學雜誌。34,85-89。 Adams, R.P. 2007. Identification of essential oil components by gas chromatography/mass spectrometry. Allured publishing corporation. Abedini S., Namdari R., Law, F. 1998. Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and chinook salmon. Aquaculture 162, 23-32. Awartani, L.S.M. 2010. Fate of Oxytetracycline and Doxycycline in Soil and Underground Water. National University. Baggot J.D., Prescott, J. 1987. Antimicrobial selection and dosage in the treatment of equine bacterial infections. Equine veterinary journal 19, 92-96. Black, W., Ferguson, H., Byrne, P., Claxton, M. 1991. Pharmacokinetic and tissue distribution study of oxytetracycline in rainbow trout following bolus intravenous administration. Journal of veterinary pharmacology and therapeutics 14, 351-358. Brentnall, C., Cheng, Z., McKellar, Q., Lees, P. 2012. Pharmacodynamics of oxytetracycline administered alone and in combination with carprofen in calves. Veterinary Record: Journal of the British Veterinary Association 171. Brentnall, C., Cheng, Z., McKellar, Q., Lees, P. 2013. Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves. Journal of veterinary pharmacology and therapeutics 36, 320-328. Bjorklund, H., Bylund, G. 1990. Temperature-related absorption and excretion of oxytetracycline in rainbow trout (Salmo gairdneri R.). Aquaculture 84, 363-372. Bjorndal K.A., Bolten A.B., Bennett R.A., Jacobson E.R., Wronski T.J., Valeski J.J., and Eliazar P.J. 1998. Age and growth in sea turtles: limitations of skeletochronology for demographic studies. Copeia 1998: 23–30. Bojs, G., Moller, H. 1974. Eczematous contact allergy to oxytetracycline with cross-sensitivity to other tetracyclines. Berufs-Dermatosen 22, 202. Brentnall C., Cheng Z., McKella, Q., Lees P. 2013. Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves. Journal of veterinary pharmacology and therapeutics 36, 320-328. Brown L. 1993. Aquaculture for veterinarians. Fish husbandry and medicine. Pergamon Press. Bumguardner, B.W., King, T.L. 1996. Toxicity of oxytetracycline and calcein to juvenile striped bass. Transactions of the American Fisheries Society 125, 143-145. Carpenter, J.W., Mashima, T.Y., Rupiper, D.J. 2012. Exotic animal formulary. Saunders. Charest, M.G., Siegel, D.R., Myers, A.G. 2005. Synthesis of (-) - tetracycline. Journal of the American Chemical Society 127, 8292-8293. Chen, Y., Mou, Q., Pan, L., Liu, Y., Wang, A., Zheng, J., Qiu, J. 2013. Establishment of drug-induced liver disease model and pathological observation in soft shell turtle Trionyx sinensis. Journal of Dalian Ocean University 1, 014. Chiayvareesajja, S., Chandumpai, A., Theapparat, Y., Faroongsarng, D. 2006. The complete analysis of oxytetracycline pharmacokinetics in farmed Pacific white shrimp (Litopenaeus vannamei). Journal of veterinary pharmacology and therapeutics 29, 409-414. Chi, Z., Liu, R., Zhang, H. 2010. Potential enzyme toxicity of oxytetracycline to catalase. Science of the total environment 408, 5399-5404. Cinquina, A., Longo, F., Anastasi, G., Giannetti, L., Cozzani, R. 2003. Validation of a high-performance liquid chromatography method for the determination of oxytetracycline, tetracycline, chlortetracycline and doxycycline in bovine milk and muscle. Journal of Chromatography A 987, 227-233. Clewell, H., Gentry, P., Gearhart, J., Allen, B., Andersen, M. 1995. Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene. Chemosphere 31, 2561-2578. Coles, W. C., J. A. Musick, and L. A. Williamson. 2001. Skeletochronology validation from an adult loggerhead (Caretta caretta). Copeia 2001: 240–242. Connell, S.R., Tracz, D.M., Nierhaus, K.H., Taylor, D.E. 2003. Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrobial agents and chemotherapy 47, 3675-3681. Coyne, R., Bergh, O., Samuelsen, O.B. 2004. One-step liquid chromatographic method for the determination of oxytetracycline in fish muscle. Journal of chromatography B 810, 325-328. Craigmill, A. 2003. A physiologically based pharmacokinetic model for oxytetracycline residues in sheep. Journal of veterinary pharmacology and therapeutics 26, 55-63. Craig A.H., Mark G.P., Andrew S., Patricia M.R., Mauricio X.R., Aleta H. 2004. Pharmacokinetics of oxytetracycline in Loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections. Journal of Zoo and wildlife Medicine. 35(4) : 477-488 Dibner, J., Richards, J. 2005. Antibiotic growth promoters in agriculture: history and mode of action. Poultry Science 84, 634-643. Elema, M.O., Hoff, K.A., Kristensen, H.G. 1996. Bioavailability of oxytetracycline from medicated feed administered to Atlantic salmon (Salmo salar L.) in seawater. Aquaculture 143, 7-14. Feng, Q., Wu, G., Liang, T., Ji, H., Jiang, X., Gu, W., Wang, W. 2011. Pharmacokinetics of oxytetracycline in hemolymph from the Chinese mitten crab, Eriocheir sinensis. Journal of veterinary pharmacology and therapeutics 34, 51-57. Finlay, A.C., Hobby, G., P'an, S., Regna, P., Routien, J., Seeley, D., Shull, G., Sobin, B., Solomons, I., Kane, J. 1950. Terramycin, a new antibiotic. American Association for the Advancement of Science. Science, 85-87. Flammer, K., D. P. Aucoin, D. A. Whitt, and D. K. Styles. 1990. Potential use of long-acting injectable oxytetracycline for treatment of chlamydiosis in Goffin's cockatoos. Avian Dis 34:228–234. Franklin, D. 1998. A natural history of North American box turtles-With information on the triage of injured and ill turtles. Journal of Wildlife Rehabilitation 21, 3-13. Frost H.M., Villanueva A.R., Roth H., and Stanisavljevic S. 1961. Tetracycline bone labeling. Journal of New drugs 1:206-216.. Gao P., Mao D., Luo Y., Wang L., Xu B., Xu L. 2012. Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment. Water research 46, 2355-2364. Giguere, S., Abrams-Ogg, A.C., Kruth, S.A. 2013. Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy. Antimicrobial Therapy in Veterinary Medicine, 359. Grondel, J., Nouws, J., Schutte, A., Driessens, F. 1989. Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus). Journal of veterinary pharmacology and therapeutics 12, 157-162. Haber, L.T., Maier, A., Zhao, Q., Dollarhide, J.S., Savage, R.E., Dourson, M.L. 2001. Applications of mechanistic data in risk assessment: the past, present, and future. Toxicological Sciences 61, 32-39. Haitao, S., Parham, J.F., Lau, M., Tien-Hsi, C. 2007. Farming endangered turtles to extinction in China. Conservation Biology 21, 5. Hansson L.I. 1967. Daily growth in length of diaphysis measured by oxytetracycline in rabbit normally and after medullary plugging. Acta orthopaedica Scandinavica. Supplementum.. 101: 1-199 Harris W.H. 1960. A microscopic method of deterrmining rates of bone growth. Nature. 188: 1038-1039. Haug T., Hals P.A. 2000. Pharmacokinetics of oxytetracycline in Arctic charr (Salvelinus alpinus L.) in freshwater at low temperature. Aquaculture, 186:175-191 Helmick K.E., Papich K.A., Vliet R.A., Bennett M.R., and Jacobson E.R. 2004. Pharmacokinetic disposition of a long-acting oxytetracycline formulation following signle-dose intravenous and intramuscular administrations in the American alligator (Alligator mississippiensis). Journal of Zoo Wildlife medicine. Haug, T., Hals, P.A. 2000. Pharmacokinetics of oxytetracyline in Arctic charr (Salvelinus alpinus L.) in freshwater at low temperature. Aquaculture 186, 175-191. Hustvedt S.O., Salte R., Vassvik V. 1991. Absorption,distribution and elemination of oxolinic acid in Atlantic salmon (Salmo salar L.) after various routes of administration. Aquaculture, 95:193-199 Hustvedt S.O., Salte R., Kvendset O., et al. 1991. Bioavailability of oxolinic acid in Atlantic salmon (Salmo salar L.) from medicated feed. Aquaculture, 97:305-310 Hustvedt S.O., Salte R. 1991. Distribution and elemination of oxolinic acid in rainbow trout (Oncorhynchus mykiss Walbaum) after a single rapid intravascular injection. Aquaculture, 92:297-303 Jacobson, E. R. 1999. Use of antimicrobial drugs in reptiles. Zoo and Wild Animal Medicine Current Therapy 4. Philadelphia, Pennsylvania. P 190–200. Jacobson, E., R. Harman, E. Laille, and L. Maxwell. 2002. Plasma concentrations of praziquantel in loggerhead sea turtles, Caretta caretta, following oral administration of single and multiple doses. Proc. Assoc. Rept. Amphib. Vet 9:37–39. Kelly, T.R., Harms, C.A., DACZM, C.L., McLellan, C., Hohn, A.A. 2006. Influence of preoperative oxytetracycline administration on community composition and antimicrobial susceptibility of cloacal bacterial flora of loggerhead sea turtle, Caretta caretta, post-hatchlings. Journal of Herpetological Medicine and Surgery Volume 16. Khosrokhavar, R., Hosseini, M.-J., Amini, M., Pirali-Hamedani, M., Ghazi-Khansari, M., Bakhtiarian, A. 2008. Validation of an analytical methodology for determination of oxytetracycline residue in milk by HPLC with UV detection. Toxicology mechanisms and methods 18, 351-354. Knox, J.H., Done, J.N., Fell, A.F., Gilbert, M., Pryde, A., Wall, R.A. 1978. High-performance liquid chromatography. Edinburgh University Press. Klinger, R. C. and J. A. Musick. 1992. Annular growth layers in juvenile loggerhead turtles (Caretta caretta). Bull. Marine Sci 51:224–230. Korsrud, G., MacNeil, J. 1988. Evaluation of the Swab Test on Premises, the Calf Antibiotic and Sulfa Test, and a Microbial Inhibitor Test with standard solutions of 22 antibiotics. Journal of food protection. Lehr D. 1957. Clinical toxicity of sulfonamides. Annals of the New York Academy of Sciences 69, 417-447. Loke, M.-L., Jespersen, S., Vreeken, R., Halling-Sorensen, B., Tjornelund, J. 2003. Determination of oxytetracycline and its degradation products by high-performance liquid chromatography–tandem mass spectrometry in manure-containing anaerobic test systems. Journal of Chromatography B 783, 11-23. Mallo, K. M., C. A. Harms, G. A. Lewbart, and M. G. Papich. 2002. Pharmacokinetics of fluconazole in loggerhead sea turtles (Caretta caretta) after single intravenous and subcutaneous injections, and multiple subcutaneous injections. J. Zoo Wildl. Med 33:29–35. Manire, C. A., H. L. Rhinehart, G. J. Pennick, D. A. Sutton, R. P. Hunter, and M. G. Rinaldi. 2003. Steady-state plasma concentrations of itraconazole after oral administration in Kemp's ridley sea turtles, Lepidochelys kempi. J. Zoo Wildl. Med 34:171–178. Marking, L.L., Howe, G.E., Crowther, J.R. 1988. Toxicity of erythromycin, oxytetracycline, and tetracycline administered to lake trout in water baths, by injection, or by feeding. The Progressive Fish-Culturist 50, 197-201. Martinsen B., Horsberg T.E., Varma K.J., et al. 1993. Single dose pharmacokinetic study of florfenicol in Atlantic salmon (Salmo salar) in seawater at 11℃. Aquaculture, 112 : 1-11 Martinsen B., Horsberg T.E. 1995. Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin, in Atlantic salmon (Salmo salar) held in seawater at 10 degrees C. Antimicrobial agents and chemotherapy 39 : 1059-1064. Meyer F., Bullock G. 1973. Edwardsiella tarda, a new pathogen of channel catfish (Ictalurus punctatus). Applied microbiology 25, 155. Mi, F.L., Wong, T.B., Shyu, S.S., Chang, S.F. 1999. Chitosan microspheres: modification of polymeric chem‐physical properties of spray‐dried microspheres to control the release of antibiotic drug. Journal of Applied Polymer Science 71, 747-759. Miller R.A., Pelsor F.R., Kane A.S., Reimschuessel R. 2012. Oxytetracycline pharmacokinetics in rainbow trout during and after an orally administered medicated feed regimen. Journal of aquatic animal health 24, 121-128. Moniot-Ville N., Guibert J., Moreau N., Acar J., Collatz E., Gutmann L. 1991. Mechanisms of quinolone resistance in a clinical isolate of Escherichia coli highly resistant to fluoroquinolones but susceptible to nalidixic acid. Antimicrobial agents and chemotherapy 35, 519-523. Morrissey, R.E., Tyl, R.W., Price, C.J., Ledoux, T.A., Reel, J.R., Paschke, L.L., Marr, M.C., Kimmel, C.A. 1986. The developmental toxicity of orally administered oxytetracycline in rats and mice. Fundamental and Applied Toxicology 7, 434-443. Namdari R.,Abedini S.,Law C.P. 1996. Tissue distribution and elimination of oxytracycline in seawater chinook and coho salmon following medicated feed treament. Aquaculture, 144:27-38 Namdari, R., Abedini, S., Albright, L., Law, F. 1998. Tissue distribution and elimination of oxytetracycline in sea-pen cultured chinook salmon, Oncorhynchus tshawytscha, and Atlantic salmon, Salmo salar, following medicated-feed treatment. Journal of Applied Aquaculture 8, 39-51 Namdari, R., Abedini, S., Law, F. 1999. A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Aquaculture research 30, 279-286. Nielsen, P., Gyrd‐Hansen, N. 1996. Bioavailability of oxytetracycline, tetracycline and chlortetracycline after oral administration to fed and fasted pigs. Journal of veterinary pharmacology and therapeutics 19, 305-311. Nordlander I., Johnsson H., Osterdahl B. 1987. Oxytetracycline residues in rainbow trout analysed by a rapid HPLC method. Food Additives & Contaminants 4, 291-296. Papich, M. G. 1999. Pharmacokinetics of enrofloxacin in reptiles. Compend. Cont. Educ. Pract. Vet 21:(Suppl. 12M). 110–114. Park E.D.,Lightner D.V.,Stamm J.M.,et al. 1994. Preliminary studies on the palatability, animal safety, and tissue residues of sarafloxacin 2HCl in the penaeid shrimp,Penaeus vannamei. Aquaculture, 126:231-241. Pato M.L., Brown G.M. 1963. Mechanisms of resistance of Escherichia coli to sulfonamides. Archives of biochemistry and biophysics 103, 443-448. Plakas, S.M., Lee, T.C., Wolke, R.E. 1988. Bioavailability of lysine in Maillard browned protein as determined by plasma lysine response in rainbow trout (Salmo gairdneri). The Journal of nutrition 118, 19-22. Plumb D.C., 1999. Veterinary Drug Handbook, 3rd ed. Iowa State Univ. Press, Ames, Iowa.475-479. Rigos, G., Alexis, M., Andriopoulou, A., Nengas, I. 2002. Pharmacokinetics and tissue distribution of oxytetracycline in sea bass, Dicentrarchus labrax, at two water temperatures. Aquaculture 210, 59-67. Rigos, G., Nengas, I., Tyrpenou, A.E., Alexis, M., Troisi, G.M. 2003. Pharmacokinetics and bioavailability of oxytetracycline in gilthead sea bream (Sparus aurata) after a single dose. Aquaculture 221, 75-83. Rigos G., Zonaras V., Nikolopoulou D., Henry M., Nikoloudaki X., Alexis M. 2011. The effect of diet composition (plant vs fish oil-based diets) on the availability of oxytetracycline in gilthead sea bream (Sparus aurata) at two water temperatures. Aquaculture 311, 31-35. Samuelsen O.B.,Bergh O.,Ervik A. 2003. A single dose pharmacokinetic study of oxolinic acid and vetoquinol, an oxolinic acid ester, in cod, Gadus morhua L., held in sea water at 8℃ and in vitro antibacterial activity of oxolinic acid against Vibrio anguillarum strains isolated from diseased cod. Fish Disease. 26:339-347 Sanderson, H., Ingerslev, F., Brain, R.A., Halling-Sorensen, B., Bestari, J.K., Wilson, C.J., Johnson, D.J., Solomon, K.R. 2005. Dissipation of oxytetracycline, chlortetracycline, tetracycline and doxycycline using HPLC–UV and LC/MS/MS under aquatic semi-field microcosm conditions. Chemosphere 60, 619-629. Schnappinger D., Hillen W. 1996. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Archives of microbiology. 165, 359-369. Schneider, M.J., Braden, S.E., Reyes-Herrera, I., Donoghue, D.J. 2007. Simultaneous determination of fluoroquinolones and tetracyclines in chicken muscle using HPLC with fluorescence detection. Journal of Chromatography B 846, 8-13. Shi X., Meng Y., Liu J., Sun A., Li D., Yao C., Lu Y., Chen J. 2011. Group-selective molecularly imprinted polymer solid-phase extraction for the simultaneous determination of six sulfonamides in aquaculture products. Journal of Chromatography B 879, 1071-1076. Singh, M., Varshneya, C., Telang, R., Srivastava, A. 2005. Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens. Journal of veterinary science 6. Skold O. 2000. Sulfonamide resistance: mechanisms and trends. Drug Resistance Updates 3, 155-160. Swann L., White M. 1991. Diagnosis and treatment of Aeromonas hydrophila infection of fish. Aquaculture Extension, Illinois-Indiana Sea Grant Program. Stamper, M. A., M. G. Papich, G. A. Lewbart, S. B. May, D. D. Plummer, and M. K. Stoskopf. 1999. Pharmacokinetics of ceftazidime in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections. J. Zoo Wildl. Med 30:32–35. Stamper, M. A., M. G. Papich, G. A. Lewbart, S. B. May, D. D. Plummer, and M. K. Stoskopf. 2003. Pharmacokinetics of florfenicol in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections. J. Zoo Wildl. Med 34:3–8. Stephens, C., Murai, K., Brunings, K., Woodward, R. 1956. Acidity constants of the tetracycline antibiotics. Journal of the American Chemical Society 78, 4155-4158. Torkildsen L., Samuelsen O.B., Lunestad B.T. 2000. Minimum inhibitory concentrations of chloramphenicol, florfenicol, trimethoprim/sulfadiazine and flumequine in seawater of bacteria associated with scallops (Pecten maximus) larvae. Aquaculture 185, 1-12. Trepanier L. 2004. Idiosyncratic toxicity associated with potentiated sulfonamides in the dog. Journal of veterinary pharmacology and therapeutics 27, 129-138. Tyrpenou A.E.,Iossifidou E.G.,Psomas I.E.et al. 2003. Tissue distribution and depletion of sarafloxacin hydrochloride after in feed administration in gilthead sea bream (Sparus aurata L.).Aquaculture, 215:291-300. Ueno, R., Kinoshita, A., Wakabayashi, J. 2004. Comparative pharmacokinetics of oxytetracycline in eel and its fate in a closed aquatic environment. Aquaculture 235, 53-63. Uno K. 1996. Pharmacokinetic study of oxytetracycline in healthy and vibriosis-infected ayu (Plecoglossus altivelis). Aquaculture 143, 33-42. Uno K.,Aoki T.,Ueno R.,et al. 1997. Pharmacokinetics and metabolism of sulphamonomethoxine in rainbowt rout (Oncorhynchus mykiss) and yellowtail (Seriola quinqueradiata) following bolus intravascular administration. Aquaculture, 153 : 1-8. Uno K., Aoki T., Kleechaya W., Tanasomwang V., Ruangpan L. 2006. Pharmacokinetics of oxytetracycline in black tiger shrimp, Penaeus monodon, and the effect of cooking on the residues. Aquaculture 254 : 24-31. Van der Heijden M. H.T.,Keukens H.J.,van den Nieuwboer W H.X.,et al. 1994. Plasma disposition of flumequinein common carp (Cyprinus carpio L,1758), African catfish(Clarias gariepinus Burchell,1822 ) and European eel (Anguilla anguilla L,1758) after a single peroral administration. Aquaculture, 123:21-30. Walsh, P. 2001. Physician's Desk Reference. Medical Economics Data Production, Montvale, New Jersey.
摘要: 本研究之目的在於運用HPLC分析技術檢測oxytetracycline (OTC) 在中華鱉組織的殘留以研究口服單一劑量30 mg/kg bw OTC 在低溫環境下於中華鱉體內之藥物動力學。本研究使用含乙二胺四乙酸二鈉 (EDTA) 之MacIlvaine buffer萃取肝臟和肌肉組織中的oxytetracycline,並以固相萃取匣 (HLB) 進行淨化濃縮後,使用HPLC進行檢測。利用 C18管柱 (5C18, 4.6 I.D. × 250 mm),移動相為 0.1 %甲酸溶液 (0.1% formic acid ):乙腈 (acetonitrile) (90:10 (v/v);pH 3)、流速1 mL/min。紫外光檢測器之波長設定為270 nm。檢測結果顯示OTC在本方法的檢測極限 (LOD) 為0.02 ppm。組織平均回收率為 78 - 103 %。單一劑量30 mg/kg B.W./day口服投予中華鱉後,血清內的藥物動力學參數如下:藥物半衰期T1/2為29.5 ± 0.22 hr,Tmax為4 ± 0 hr,Cmax為2.17 ± 0.32 mg/kg,MRT為40.0 ± 10.2 hr,AUCinf為1,443 ± 92.3 hr-μg/mL。在20 ℃飼養環境下,給藥後第一天可測得肌肉和肝臟組織平均濃度為480 ppb和620 ppb,第二天殘留量為470 ppb和390 ppb,最後至給藥後第20天降至80 ppb和90 ppb,於給藥後第24天皆低於檢測極限。
The aims of this study were to study the oxytetracycline (OTC) pharmacokinetics and tissue residual levels in Chinese soft-shell turtle, Pelodiscus sinensis, by single dose oral adminstation at 20℃, using the high-performance liquid chromatography (HPLC) technique. The OTC was extracted from various tissue of soft-shelled turtles with MaccIlvaine buffer by solid-phase extraction. HPLC method was set with C18 coloume for separation of OTC with the mobile phase of 0.1% formic acid and acetonitrile (90:10, v/v; pH 3). Flow rate was 1 mL/min, and the UV-detector at wavelength 270 nm. The results revealed that the detector limit was 0.02ppm. The recoveries of serum, muscle, and liver were 88-98%, 70-87%, and 98-103%, respectively. After given single dose 30 mg/kgw/day of OTC by oral administration, the results of pharmacokinetic parameter of T1/2, Tmax, Cmax, Mean residence time (MRT), and AUCinf were 29.5 ± 0.22 hr, 4 ± 0 hr, 2.17 ± 0.32 mg/kg, 40.0 ± 10.2 hr, and 1,443 ± 92.3 hr-μg/mL, respectively. At 20℃, the average drug residue concentration in muscle and liver in the first and second day after administration was (480 and 620 ppb) and (470 and 390 ppb), respectively. The residue concentrations in muscle and liver were both below the detection limit (lower 50 ppb) at the 24th day, respectively.
URI: http://hdl.handle.net/11455/93023
其他識別: U0005-2306201413293200
文章公開時間: 2017-06-25
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