Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/94021
標題: Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response
作者: Lin, Ming-Kuem
Lee, Meng-Shiou
Chang, Wen-Te
Chen, Hsing-Yu
Chen, Jin-Fu
Li, Yi-Rong
Lin, Chi-Chen
Wu, Tian-Shung
關鍵字: Contact hypersensitivity response
Dendritic cell
Immunosuppression
Taiwanofungus camphoratus
Zhankuic acid C
Animals
Anti-Inflammatory Agents
Basidiomycota
Cell Line, Tumor
Chemokines
Cytokines
Dendritic Cells
Dermatitis, Contact
Dose-Response Relationship, Drug
Ergosterol
Humans
Lipopolysaccharides
Mice
Molecular Conformation
Structure-Activity Relationship
Immunosuppression
摘要: Some ergostane triterpenoids from Taiwanofungus camphoratus have been shown to exhibit anti-inflammatory activity in vitro. However, the effect of ergostane triterpenoids on the immune response remains unknown. In this study, we elucidated that ergostane triterpenoids significantly decreased the cytokines and chemokine release by dendritic cells (DC) and that, in the case of zhankuic acid C (ZAC), the decrease was dose-dependent and inhibited DC maturation. ZAC inhibited the contact hypersensitivity response and infiltrative T cells in the ears of DNFB-stimulated mice. Thus, we demonstrate for the first time that ZAC exhibits an immunosuppressive effect on DC activation and the contact hypersensitivity response. It is suggested that ZAC can potentially be used for treating chronic inflammation and autoimmune diseases.
URI: http://hdl.handle.net/11455/94021
Appears in Collections:生物醫學研究所

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