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標題: 純植物化合物Cytopiloyne 透過GATA-3 途徑且影響PKCα之路徑抑制脂肪細胞的分化
作者: 潘乃蓁
關鍵字: 大花咸豐草萃取物
出版社: 獸醫學系暨研究所
摘要: 有些天然植物化合物具有抑制脂肪細胞分化及誘導脂肪細胞凋亡的能力。脂肪細胞分化包含許多基因表現因子的調控作用,如peroxisome proliferator activated receptor-γ (PPARγ) 及GATA binding protein-3 (GATA-3)。在我們的研究中證實由大花咸豐草萃取出的植物化合物cytopiloyne (CP),可以抑制不同動物來源的脂肪細胞分化。我們也證實出CP透過GATA-3途徑抑制脂肪細胞分化。我們實驗室已有的數據指出CP能調節RAW264.7巨噬細胞及RIN-m5F胰島細胞的PKCα膜到質轉位作用。近年來的文獻亦指出,PKCα和鈣離子之結合蛋白calreticulin (CRT) 的表現情形會影響脂肪細胞分化情形。因此,我們未來也將探討CP對PKCα、CRT 及 Ca2+ 之間的關係。Certain nature compounds have ability to inhibit adipogenesis and induce apoptosis in adipocytes. Adipocyte differentiation involves a temporally regulation set of gene-expression events, such as peroxisome proliferator activated receptor-γ (PPARγ) and GATA binding protein-3 (GATA-3). In our investigation, we found cytopiloyne (CP), a phytocompound from Bidens pilosa, can reduce the differentiation of adipocytes from various animal sources. We also proved CP inhibits adipocyte differentiation through the GATA-3 pathway in 3T3-L1 cells. Our previous results showed CP can regulate the expression of PKCα translocation in RAW264.7 macrophages and RIN-m5F β-cells. Recent papers indicated that the expression of PKCα and calreticulin (CRT), the major Ca2+-binding protein, can regulate the adipogenesis in 3T3-L1 cells. Therefore, we will focus the adipogenic effect of CP on interaction among PKCα, CRT and Ca2+.
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