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標題: Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy
作者: Lee, Wen-Jane
Liu, Shing-Hwa
Chiang, Chih-Kang
Lin, Shih-Yi
Liang, Kae-Woei
Chen, Cheng-Hsu
Tien, Hsing-Ru
Chen, Pei-Hsuan
Wu, Jen-Pey
Tsai, Yi-Ching
Lai, De-Wei
Chang, Yi-Chieh
Sheu, Wayne Huey-Herng
Sheu, Meei-Ling
關鍵字: Animals
Basic Helix-Loop-Helix Transcription Factors
Blood Glucose
Diabetes Mellitus, Experimental
Diabetic Nephropathies
Extracellular Matrix
Gene Expression Regulation
Lipid Peroxidation
Mesangial Cells
Oxidative Stress
Reactive Oxygen Species
Receptors, Aryl Hydrocarbon
摘要: Activation of glomerular mesangial cells (MCs) and functional changes of renal tubular cells are due to metabolic abnormalities, oxidative stress, and matrix accumulation in the diabetic nephropathy (DN). Aryl hydrocarbon receptor (AhR) activation has been implicated in DN. In this study, we investigated the role of AhR in the pathophysiological processes of DN using AhR knockout (AhRKO) and pharmacological inhibitor α-naphthoflavone mouse models.
Appears in Collections:生物醫學研究所



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