請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/94821
標題: Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways
作者: Liang, Yu-Chuan
Yang, Meng-Ting
Lin, Chuan-Ju
Chang, Cicero Lee-Tian
Yang, Wen-Chin
關鍵字: 3T3-L1 Cells
Adipogenesis
Adipose Tissue
Animals
Bidens
CCAAT-Enhancer-Binding Proteins
Down-Regulation
Early Growth Response Protein 2
Female
Lipid Metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Obese
PPAR gamma
Plant Extracts
RNA, Messenger
Signal Transduction
Thiazolidinediones
摘要: Obesity and its complications are a major global health problem. In this study, we investigated the anti-obesity effect and mechanism of an edible plant, Bidens pilosa, and its active constituent. We first assessed the long-term effect of B. pilosa on body composition, body weight, blood parameters in ICR mice. We observed that it significantly decreased fat content and increased protein content in ICR mice. Next, we verified the anti-obesity effect of B. pilosa in ob/ob mice. It effectively and dose-dependently reduced fat content, adipocyte size and/or body weight in mice. Moreover, mechanistic studies showed that B. pilosa inhibited the expression of peroxisome proliferator activated receptor γ (PPARγ), CCAAT/enhancer binding proteins (C/EBPs) and Egr2 in adipose tissue. Finally, we examined the effect of 2-β-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne (GHT) on adipogenesis in adipocytes. We found that B. pilosa significantly decreased the adipogenesis and lipid accumulation. This decrease was associated with the down-regulation of expression of Egr2, C/EBPs, PPARγ, adipocyte Protein 2 (aP2) and adiponectin. In summary, this work demonstrated that B. pilosa and GHT suppressed adipogenesis and lipid content in adipocytes and/or animals via the down-regulation of the Egr2, C/EBPs and PPARγ pathways, suggesting a novel application of B. pilosa and GHT against obesity.
URI: http://hdl.handle.net/11455/94821
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