請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/94830
標題: Pharmacokinetics and tissue depletion of doxycycline administered at high dosage to broiler chickens via the drinking water
作者: Hsiao, Pai-Feng
Chang, Shao-Kuang
Hsu, Tien-Huan
Li, Kuang-Po
Chou, Chi-Chung
關鍵字: Doxycycline hyclate
broiler
heart and gizzard
pharmacokinetics
withdrawal time
Animals
Area Under Curve
Dose-Response Relationship, Drug
Doxycycline
Drinking Water
Drug Residues
Half-Life
Chickens
摘要: The recommended use of doxycycline (DC) to broiler chicken is 100 mg/L via the drinking water and a 7-day withdrawal time (WDT). However, study of a higher dosage is desirable because of the possible increase of antimicrobial resistance and disease spectrum. Tissue DC residues exceeding the current maximum residue levels (MRL) was our major concern. Therefore, serum concentration and tissue depletion of DC hyclate after administration of 200 mg/L of DC in the drinking water for five consecutive days were studied. The steady-state DC concentration (8.3 ± 0.9 μg/mL) was reached on the third day of medication. The elimination constant (0.05 ± 0.01 1/h), half-life (14.9 ± 1.4 h), area under concentration versus time curve (81.0 ± 9.9 h·μg/mL) and mean residence time (22.7 ± 2.5 h) were obtained using a non-compartmental pharmacokinetic model. It was determined that the current 7-day WDT regulation was still legitimate for the kidney and liver as well as for the breast and leg muscles, which were estimated by linear regression analysis of the 99% upper distribution limit. The unregulated heart and gizzard were considered safe even when the lowest MRL of muscle (100 ng/g) was applied. While at the present time the extra-label use of drugs is only allowed under specific conditions, in the future it may become necessary to increase the general dosage of DC, and the current results suggest a safe range of DC hyclate in chicken; however, skin/fat tissue residues warrant further studies.
URI: http://hdl.handle.net/11455/94830
ISSN: 0236-6290
顯示於類別:獸醫學系所

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