Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/94860
標題: Highly Efficient Synthesis of an Emerging Lipophilic Antioxidant: 2-Ethylhexyl Ferulate
作者: Huang, Kuo-Chuan
Li, Ying
Kuo, Chia-Hung
Twu, Yawo-Kuo
Shieh, Chwen-Jen
關鍵字: 2-ethylhexyl ferulate
artificial neural network
lipase
reduced pressure evaporation system
response surface methodology
Antioxidants
Coumaric Acids
Esters
Hexanols
Lipase
Lipid Peroxidation
Neural Networks (Computer)
Solvents
摘要: Ferulic acid in ester form has shown a stronger ability in ameliorating certain pathological conditions and inhibiting lipid oxidation. In present study, a solvent-free and reduced pressure evaporation system was developed for lipase-catalyzed synthesis of 2-ethylhexyl ferulate (2-EF) from ferulic acid and 2-ethylhexanol. A Box-Behnken design with response surface methodology (RSM) and artificial neural network (ANN) was selected to model and optimize the process. Based on the yields of 2-EF, reaction temperature was shown to be the most important process factor on the molar conversion among all variables. The residual values and the coefficient of determination (R²) calculated from the design data indicated that ANN was better than RSM in data fitting. Overall, the present lipase-catalyzed approach for 2-EF synthesis at low reaction temperature in a reduced pressure evaporation system shows high 2-EF production efficiency. Notably, this approach can reduce the enzyme denaturation and ferulic acid oxidation that usually occur during long-term biosynthetic operations at high temperature.
URI: http://hdl.handle.net/11455/94860
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