請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/95848
標題: Steroidogenic enzymes of adipose tissue in modulation of trivalent chromium in a mouse model of PCOS
作者: Chen, Tsung-Sheng
Chen, Yi-Ting
Liu, Chia-Hsin
Sun, Chi-Ching
毛嘉洪
Mao, Frank Chiahung
關鍵字: Adipose tissue
dehydroepiandrosterone
polycystic ovary syndrome
steroidogenic enzymes
trivalent chromium
17-Hydroxysteroid Dehydrogenases
Adipose Tissue
Animals
Aromatase
Chromium
Dehydroepiandrosterone
Disease Models, Animal
Female
Mice
Mice, Inbred BALB C
Polycystic Ovary Syndrome
Trace Elements
出版社: GYNECOLOGICAL ENDOCRINOLOGY
摘要: Polycystic ovary syndrome (PCOS) is a type of endocrine metabolic disorder with many different consequences to health, most commonly infertility, obesity and insulin resistance. Trivalent chromium (Cr3+) was previously found to improve the metabolic profiles of patients with PCOS. The aim of this study was to explore the effect of Cr on regulating steroidogenic enzymes in adipose tissue. Female BALB/c mice were divided into three groups (n = 6 per group): the control group, PCOS + placebo milk group and PCOS + Cr-containing milk group. The dietary intake of Cr significantly decreased fasting blood sugar (FBS) and homeostasis model assessment of insulin resistance levels in the murine model of PCOS. Importantly, we found significant correlations among the levels of Cr, insulin and dehydroepiandrosterone (DHEA). In adipose tissue, decreases in the enzyme expressions of 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase, but not of aromatase, were observed. By understanding the role of steroidogenic enzymes in PCOS in normal and pathological states, trace elements may be used as a form of adjunctive therapy in the management of patients with PCOS.
URI: http://hdl.handle.net/11455/95848
顯示於類別:獸醫學系所

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。