Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/96058
DC FieldValueLanguage
dc.contributor顏國欽zh_TW
dc.contributor.authorChia-Ying Linen_US
dc.contributor.author林佳瑩zh_TW
dc.contributor.other食品暨應用生物科技學系所zh_TW
dc.date2017zh_TW
dc.date.accessioned2018-12-17T03:21:00Z-
dc.identifier.citation行政院衛生福利部。衛福部審核通過之健康食品一覽表,https://consumer.fda.gov.tw/Food/InfoHealthFood.aspx?nodeID=162 。2017。 尹華文、呂勝由等,苦茶油、茶籽油與茶樹精油之辨別、萃取及其利用。林業研究專訊 Vol.17 No.4 2010。 王振瀾、林玉含,優良品種油茶油脂成分的提煉及性質分析。林業試驗所研究報告季刊,1990,5:11-15。 杜邦碩,苦茶油對乙醇誘導小鼠急性腸胃黏膜損傷之保護效應。國立中興大學 食品暨應用生物科技學系碩士論文,2016。 黃裕星與尹華文,油茶栽培管理與利用手冊。行政原農業委員會林業試驗所,2013。 臺灣原生山茶屬植物分類介紹,翁世豪。行政院農業委員會茶業改良場,http://www.tres.gov.tw。 蔡敏雄,免疫運作力─體內制衡健康方法。大康出版社。台灣 台北市,2004。 蔡智能、劉明輝。科學發展,Vol.377 2004。 謝志享,以初代免疫細胞培養評估不同食材之免疫調節傾向並探討桑椹多醣對卵白蛋白致敏小鼠之免疫調節功能。國立中興大學食品暨應用生物科技學系碩士論文,2007。 顏正賢,自體免疫疾病--會自己攻擊自己的疾病。高醫醫訊,2010 Abautret-Daly, A.; Dempsey, E.; Parra-Blanco, A.; Medina, C.; Harkin, A., Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease. Acta Neuropsychiatr 2017, 1-22. Abbas, A. K.; Lichtman, A. H.; Pillai, S., 2015. Cellular and molecular immunology, Eighth edition. ed. Elsevier Saunders, Philadelphia, PA. Abreu, M. T., Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol 2010, 10, 131-144. Angela, M.; Endo, Y.; Asou, H. K.; Yamamoto, T.; Tumes, D. J.; Tokuyama, H.; Yokote, K.; Nakayama, T., Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARgamma directs early activation of T cells. Nat Commun 2016, 7, 13683. Aparicio-Soto, M.; Sanchez-Hidalgo, M.; Rosillo, M. A.; Castejon, M. L.; Alarcon-de-la-Lastra, C., Extra virgin olive oil: a key functional food for prevention of immune-inflammatory diseases. Food Funct 2016, 7, 4492-4505. Arango Duque, G.; Descoteaux, A., Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol 2014, 5, 491. Battaglia, M.; Gianfrani, C.; Gregori, S.; Roncarolo, M. G., IL-10-producing T regulatory type 1 cells and oral tolerance. Ann N Y Acad Sci 2004, 1029, 142-153. Bronte, V.; Pittet, M. J., The spleen in local and systemic regulation of immunity. Immunity 2013, 39, 806-818. Buckland, G.; Gonzalez, C. A., The role of olive oil in disease prevention: a focus on the recent epidemiological evidence from cohort studies and dietary intervention trials. Br J Nutr 2015, 113 Suppl 2, S94-101. Bulotta, S.; Celano, M.; Lepore, S. M.; Montalcini, T.; Pujia, A.; Russo, D., Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases. J Transl Med 2014, 12, 219. Bumrungpert, A.; Pavadhgul, P.; Kalpravidh, R. W., Camellia Oil-Enriched Diet Attenuates Oxidative Stress and Inflammatory Markers in Hypercholesterolemic Subjects. J Med Food 2016, 19, 895-898. Calder, P. C., Fatty acids, dietary lipids and lymphocyte functions. Biochem Soc Trans 1995, 23, 302-309. Calder, P. C.; Costa-Rosa, L. F.; Curi, R., Effects of feeding lipids of different fatty acid compositions upon rat lymphocyte proliferation. Life Sci 1995, 56, 455-463. Camell, C.; Smith, C. W., Dietary oleic acid increases m2 macrophages in the mesenteric adipose tissue. PLoS One 2013, 8, e75147. Casas, R.; Sacanella, E.; Estruch, R., The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases. Endocr Metab Immune Disord Drug Targets 2014, 14, 245-254. Chandrasekar, B.; Fernandes, G., Decreased pro-inflammatory cytokines and increased antioxidant enzyme gene expression by omega-3 lipids in murine lupus nephritis. Biochem Biophys Res Commun 1994, 200, 893-898. Chehade, M.; Mayer, L., Oral tolerance and its relation to food hypersensitivities. J Allergy Clin Immunol 2005, 115, 3-12; quiz 13. Cheng, P. C.; Huang, C. C.; Chiang, P. F.; Lin, C. N.; Li, L. L.; Lee, T. W.; Lin, B.; Chen, I. C.; Chang, K. W.; Fan, C. K.; Luo, T. Y., Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells. Int J Radiat Biol 2014a, 90, 841-852. Cheng, Y. T.; Wu, S. L.; Ho, C. Y.; Huang, S. M.; Cheng, C. L.; Yen, G. C., Beneficial effects of Camellia Oil (Camellia oleifera Abel.) on ketoprofen-induced gastrointestinal mucosal damage through upregulation of HO-1 and VEGF. J Agric Food Chem 2014b, 62, 642-650. Chistiakov, D. A.; Orekhov, A. N.; Bobryshev, Y. V., Immune-inflammatory responses in atherosclerosis: Role of an adaptive immunity mainly driven by T and B cells. Immunobiology 2016, 221, 1014-1033. Cho, J. H.; Kim, H. O.; Kim, K. S.; Yang, D. H.; Surh, C. D.; Sprent, J., Unique features of naive CD8+ T cell activation by IL-2. J Immunol 2013, 191, 5559-5573. Clemente, T. E.; Cahoon, E. B., Soybean oil: genetic approaches for modification of functionality and total content. Plant Physiol 2009, 151, 1030-1040. Dawczynski, C.; Dittrich, M.; Neumann, T.; Goetze, K.; Welzel, A.; Oelzner, P.; Volker, S.; Schaible, A. M.; Troisi, F.; Thomas, L.; Pace, S.; Koeberle, A.; Werz, O.; Schlattmann, P.; Lorkowski, S.; Jahreis, G., Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil. Clin Nutr 2017. de Lima, T. M.; de Sa Lima, L.; Scavone, C.; Curi, R., Fatty acid control of nitric oxide production by macrophages. FEBS Lett 2006, 580, 3287-3295. de Pablo, M. A.; Alvarez de Cienfuegos, G., Modulatory effects of dietary lipids on immune system functions. Immunol Cell Biol 2000, 78, 31-39. de Pablo, M. A.; Ortega, E.; Gallego, A. M.; Alvarez, C.; Pancorbo, P. L.; Alvarez de Cienfuegos, G., The effect of dietary fatty acid manipulation on phagocytic activity and cytokine production by peritoneal cells from Balb/c mice. J Nutr Sci Vitaminol (Tokyo) 1998, 44, 57-67. Diaz-de-Durana, Y.; Lau, J.; Knee, D.; Filippi, C.; Londei, M.; McNamara, P.; Nasoff, M.; DiDonato, M.; Glynne, R.; Herman, A. E., IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes. PLoS One 2013, 8, e78483. Donato-Trancoso, A.; Monte-Alto-Costa, A.; Romana-Souza, B., Olive oil-induced reduction of oxidative damage and inflammation promotes wound healing of pressure ulcers in mice. J Dermatol Sci 2016, 83, 60-69. Eilat, D., Introduction: mechanisms of tissue injury in autoimmune diseases. Semin Immunopathol 2014, 36, 491-493. Endah Puji Septisetyani; Ratih Asmana Ningrum; Yulaika Romadhani; Hadi, P.; Wisnuwardhani; Santoso, A., Optimization of sodium dodecyl sulphate as a formazan solvent and comparison of 3-(4,-5-dimethylthiazo-2-YL)-2,5-diphenyltetrazolium bromide (MTT) assay with wst-1 assay in MCF-7 CELLS. Indonesian Journal of Clinical Pharmacy 2014, 25, 245-254. Fernandes, G.; Bysani, C.; Venkatraman, J. T.; Tomar, V.; Zhao, W., Increased TGF-beta and decreased oncogene expression by omega-3 fatty acids in the spleen delays onset of autoimmune disease in B/W mice. J Immunol 1994, 152, 5979-5987. Frossard, C. P.; Tropia, L.; Hauser, C.; Eigenmann, P. A., Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy. J Allergy Clin Immunol 2004, 113, 958-964. Gorjao, R.; Cury-Boaventura, M. F.; de Lima, T. M.; Curi, R., Regulation of human lymphocyte proliferation by fatty acids. Cell Biochem Funct 2007, 25, 305-315. Haimeur, A.; Mimouni, V.; Ulmann, L.; Martineau, A. S.; Messaouri, H.; Pineau-Vincent, F.; Tremblin, G.; Meskini, N., Fish Oil and Microalga Omega-3 as Dietary Supplements: A Comparative Study on Cardiovascular Risk Factors in High-Fat Fed Rats. Lipids 2016, 51, 1037-1049. Heller, A. R.; Theilen, H. J.; Koch, T., Fish or chips? News Physiol Sci 2003, 18, 50-54. Her, M.; Kavanaugh, A., Alterations in immune function with biologic therapies for autoimmune disease. J Allergy Clin Immunol 2016, 137, 19-27. Hirohata, S.; Abe, A.; Murasawa, A.; Kanamono, T.; Tomita, T.; Yoshikawa, H., Differential effects of IL-6 blockade tocilizumab and TNF inhibitors on angiogenesis in synovial tissues from patients with rheumatoid arthritis. Mod Rheumatol 2016, 1-7. Honda, A.; Fukushima, W.; Oishi, M.; Tsuji, K.; Sawahara, T.; Hayashi, T.; Kudo, H.; Kashima, Y.; Takahashi, K.; Sasaki, H.; Ueda, K.; Takano, H., Effects of components of PM2.5 collected in Japan on the respiratory and immune systems. Int J Toxicol 2017, 1091581816682224. Italiani, P.; Boraschi, D., From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation. Front Immunol 2014, 5, 514. Jani, R. H.; Gupta, R.; Bhatia, G.; Rathi, G.; Ashok Kumar, P.; Sharma, R.; Kumar, U.; Gauri, L. A.; Jadhav, P.; Bartakke, G.; Haridas, V.; Jain, D.; Mendiratta, S. K., A prospective, randomized, double-blind, multicentre, parallel-group, active controlled study to compare efficacy and safety of biosimilar adalimumab (Exemptia; ZRC-3197) and adalimumab (Humira) in patients with rheumatoid arthritis. Int J Rheum Dis 2016, 19, 1157-1168. Jiang, S.; Han, S.; Chen, J.; Li, X.; Che, H., Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice. Ann Allergy Asthma Immunol 2017, 118, 94-102. Jones, E. L.; Demaria, M. C.; Wright, M. D., Tetraspanins in cellular immunity. Biochem Soc Trans 2011, 39, 506-511. Jung, C.; Hugot, J. P.; Barreau, F., Peyer's Patches: The immune sensors of the intestine. Int J Inflam 2010, 2010, 823710. Jung, E.; Lee, J.; Baek, J.; Jung, K.; Lee, J.; Huh, S.; Kim, S.; Koh, J.; Park, D., Effect of Camellia japonica oil on human type I procollagen production and skin barrier function. J Ethnopharmacol 2007, 112, 127-131. Kang, S.; Min, H., Ginseng, the 'Immunity Boost': The effects of panax ginseng on immune system. J Ginseng Res 2012, 36, 354-368. Karine Thoreux, R. O., Douglas L. Schmucker, Functional foods, mucosal immunity and aging: effect of probiotics on intestinal immunity in young and old rats. Communicating Current Research and Educational Topics and Trends in Applied Microbiology 2007. Kashina, S.; Villavicencio, L. L.; Zaina, S.; Ordaz, M. B.; Sabanero, G. B.; Fujiyoshi, V. T.; Lopez, M. S., Activity of extracts from submerged cultured mycelium of winter mushroom, flammulina velutipes (Agaricomycetes), on the immune system in vitro. Int J Med Mushrooms 2016, 18, 49-57. Kidd, P., Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 2003, 8, 223-246. Kim, S.; Jung, E.; Shin, S.; Kim, M.; Kim, Y. S.; Lee, J.; Park, D., Anti-inflammatory activity of Camellia japonica oil. BMB Rep 2012, 45, 177-182. Kim, S.; Karasuyama, H.; Lopez, A. F.; Ouyang, W.; Li, X.; Le Gros, G.; Min, B., IL-4 derived from non-T cells induces basophil- and IL-3-independent Th2 immune responses. Immune Netw 2013, 13, 249-256. Kozic Dokmanovic, S.; Kolovrat, K.; Laskaj, R.; Jukic, V.; Vrkic, N.; Begovac, J., Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: A randomized, crossover, controlled clinical trial. Med Sci Monit 2015, 21, 2406-2413. Kucukgul, A.; Erdogan, S., Low concentration of oleic acid exacerbates LPS-induced cell death and inflammation in human alveolar epithelial cells. Exp Lung Res 2017, 43, 1-7. Kuldeep Dhama, M. S., Siju Susan Jacob, Mithilesh Singh, K. Karthik, Amarpal , Ruchi Tiwari, Lakshmi Tulasi Sunkara, Yashpal Singh Malik and Raj Kumar Singh, Effect of immunomodulation and immunomodulatory agents on health with some bioactive principles, modes of action and potent biomedical applications. Int.J. Pharmacol 2015, 11, 253-290. la Torre Fabiola, V. D.; Ralf, K.; Gabriel, B.; Victor Ermilo, A. A.; Martha, M. G.; Mirbella, C. F.; Rocio, B. A., Anti-inflammatory and immunomodulatory effects of Critonia aromatisans leaves: Downregulation of pro-inflammatory cytokines. J Ethnopharmacol 2016, 190, 174-182. Lee, C. P.; Shih, P. H.; Hsu, C. L.; Yen, G. C., Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol 2007, 45, 888-895. Lee, W. J.; Tateya, S.; Cheng, A. M.; Rizzo-DeLeon, N.; Wang, N. F.; Handa, P.; Wilson, C. L.; Clowes, A. W.; Sweet, I. R.; Bomsztyk, K.; Schwartz, M. W.; Kim, F., M2 macrophage polarization mediates anti-inflammatory effects of endothelial nitric oxide signaling. diabetes 2015, 64, 2836-2846. Levast, B.; Li, Z.; Madrenas, J., The role of IL-10 in microbiome-associated immune modulation and disease tolerance. Cytokine 2015, 75, 291-301. Li, W. J.; Tang, X. F.; Shuai, X. X.; Jiang, C. J.; Liu, X.; Wang, L. F.; Yao, Y. F.; Nie, S. P.; Xie, M. Y., Mannose receptor mediates the immune response to ganoderma atrum polysaccharides in macrophages. J Agric Food Chem 2017, 65, 348-357. Liao, W.; Lin, J. X.; Leonard, W. J., IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol 2011, 23, 598-604. Lin, T. J.; Hirji, N.; Stenton, G. R.; Gilchrist, M.; Grill, B. J.; Schreiber, A. D.; Befus, A. D., Activation of macrophage CD8: pharmacological studies of TNF and IL-1 beta production. J Immunol 2000, 164, 1783-1792. Liu, X.; Jia, L.; Gao, Y.; Li, B.; Tu, Y., Anti-inflammatory activity of total flavonoids from seeds of Camellia oleifera Abel. Acta Biochim Biophys Sin (Shanghai) 2014, 46, 920-922. Lozovoy, M. A.; Simao, A. N.; Morimoto, H. K.; Scavuzzi, B. M.; Iriyoda, T. V.; Reiche, E. M.; Cecchini, R.; Dichi, I., Fish oil N-3 fatty acids increase adiponectin and decrease leptin levels in patients with systemic lupus erythematosus. Mar Drugs 2015, 13, 1071-1083. Martin, S. J., Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system. FEBS J 2016, 283, 2599-2615. Martinet, W.; Schrijvers, D. M.; Timmermans, J. P.; Herman, A. G.; De Meyer, G. R., Phagocytosis of bacteria is enhanced in macrophages undergoing nutrient deprivation. FEBS J 2009, 276, 2227-2240. Meenakshi, P.; Ramya, S.; Lavanya, J.; Vijayalakshmi, V.; Sumanlatha, G., Effect of IFN-gamma, IL-12 and IL-10 cytokine production and mRNA expression in tuberculosis patients with diabetes mellitus and their household contacts. Cytokine 2016, 81, 127-136. Melo, G. D.; Seraguci, T. F.; Schweigert, A.; Silva, J. E.; Grano, F. G.; Peiro, J. R.; Lima, V. M.; Machado, G. F., Pro-inflammatory cytokines predominate in the brains of dogs with visceral leishmaniasis: a natural model of neuroinflammation during systemic parasitic infection. Vet Parasitol 2013, 192, 57-66. Menotti, A.; Puddu, P. E., [Historic origins of the mediterranean diet: the Seven Countries Study of Cardiovascular Diseases]. Epidemiol Prev 2015, 39, 285-288. Monk, J. M.; Kim, W.; Callaway, E.; Turk, H. F.; Foreman, J. E.; Peters, J. M.; He, W.; Weeks, B.; Alaniz, R. C.; McMurray, D. N.; Chapkin, R. S., Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARdelta in inflammation-induced colon carcinogenesis. Am J Physiol Gastrointest Liver Physiol 2012, 302, G153-167. Mourouti, N.; Panagiotakos, D. B., The beneficial effect of a Mediterranean diet supplemented with extra virgin olive oil in the primary prevention of breast cancer among women at high cardiovascular risk in the PREDIMED Trial. Evid Based Nurs 2016, 19, 71. Myles, I. A., Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr J 2014, 13, 61. Niu, Y.; Dong, Q.; Li, R., Matrine regulates Th1/Th2 cytokine responses in rheumatoid arthritis by attenuating the NF-KappaB signaling. Cell Biol Int 2017. Owen, J. A.; Punt, J.; Kuby, J.; Stranford, S. A., 2013a. Kuby Immunology, W.H. Freeman. Owen, J. A.; Punt, J.; Stranford, S. A.; Jones, P. P.; Kuby, J., 2013b. Kuby immunology, 7th ed. W.H. Freeman, New York. Parham, P.; Janeway, C., 2015. The immune system, Fourth edition. ed. Garland Science, Taylor & Francis Group, New York, NY. Parker, D. C., How does the helper T cell activate the resting B cell when it recognizes antigen on the B-cell surface? Res Immunol 1990, 141, 405-407. Pasparakis, M.; Alexopoulou, L.; Episkopou, V.; Kollias, G., Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 1996, 184, 1397-1411. Patterson, E.; Wall, R.; Fitzgerald, G. F.; Ross, R. P.; Stanton, C., Health implications of high dietary omega-6 polyunsaturated fatty acids. J Nutr Metab 2012, 2012, 539426. Petursdottir, D. H.; Hardardottir, I., Dietary fish oil decreases secretion of T helper (Th) 1-type cytokines by a direct effect on murine splenic T cells but enhances secretion of a Th2-type cytokine by an effect on accessory cells. Br J Nutr 2009, 101, 1040-1046. Potentas, E.; Witkowska, A. M.; Zujko, M. E., Mediterranean diet for breast cancer prevention and treatment in postmenopausal women. Prz Menopauzalny 2015, 14, 247-253. Raskov, H.; Burcharth, J.; Pommergaard, H. C.; Rosenberg, J., Irritable bowel syndrome, the microbiota and the gut-brain axis. Gut Microbes 2016, 7, 365-383. Refaeli, Y.; Van Parijs, L.; London, C. A.; Tschopp, J.; Abbas, A. K., Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 1998, 8, 615-623. Robinson, T. M.; Nelson, R. G.; Boyer, J. D., Parasitic infection and the polarized Th2 immune response can alter a vaccine-induced immune response. DNA Cell Biol 2003, 22, 421-430. Rogala, B.; Bozek, A.; Gluck, J.; Jarzab, J., Prevalence of IgE-mediated allergy and evaluation of Th1/Th2 cytokine profiles in patients with severe bronchial asthma. Postepy Dermatol Alergol 2015, 32, 274-280. Rosillo, M. A.; Alarcon-de-la-Lastra, C.; Sanchez-Hidalgo, M., An update on dietary phenolic compounds in the prevention and management of rheumatoid arthritis. Food Funct 2016, 7, 2943-2969. Santarlasci, V.; Cosmi, L.; Maggi, L.; Liotta, F.; Annunziato, F., IL-1 and T helper immune responses. Front Immunol 2013, 4, 182. Schmitt, N.; Ueno, H., Regulation of human helper T cell subset differentiation by cytokines. Curr Opin Immunol 2015, 34, 130-136. Siscovick, D. S.; Barringer, T. A.; Fretts, A. M.; Wu, J. H.; Lichtenstein, A. H.; Costello, R. B.; Kris-Etherton, P. M.; Jacobson, T. A.; Engler, M. B.; Alger, H. M.; Appel, L. J.; Mozaffarian, D.; American Heart Association Nutrition Committee of the Council on, L.; Cardiometabolic, H.; Council on, E.; Prevention; Council on Cardiovascular Disease in the, Y.; Council on, C.; Stroke, N.; Council on Clinical, C., Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease: A science advisory from the American heart association. Circulation 2017. Sravanthi, V., Oleic acid nanoemulsion for nasal vaccination: Impact on adjuvanticity based immune response. J Drug Deliv Sci Tec 28 2015, 56-63. Tanabe, T.; Yamaguchi, N.; Okuda, M.; Ishimaru, Y.; Takahashi, H., Immune system reaction against environmental pollutants. Nihon Eiseigaku Zasshi 2015, 70, 115-119. Tanaka, T.; Narazaki, M.; Kishimoto, T., IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 2014, 6, a016295. Taranu, I.; Gras, M.; Pistol, G. C.; Motiu, M.; Marin, D. E.; Lefter, N.; Ropota, M.; Habeanu, M., omega-3 PUFA rich camelina oil by-products improve the systemic metabolism and spleen cell functions in fattening pigs. PLoS One 2014, 9, e110186. Tortosa-Caparros, E.; Navas-Carrillo, D.; Marin, F.; Orenes-Pinero, E., Anti-inflammatory Effects of omega 3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome. Crit Rev Food Sci Nutr 2016, 0. Twigg, H. L., 3rd, Humoral immune defense (antibodies): recent advances. Proc Am Thorac Soc 2005, 2, 417-421. Wang, Y.; Huang, M.; Sun, R.; Pan, L., Extraction, characterization of a Ginseng fruits polysaccharide and its immune modulating activities in rats with Lewis lung carcinoma. Carbohydr Polym 2015, 127, 215-221. Xia, C. Q.; Peng, R.; Chernatynskaya, A. V.; Yuan, L.; Carter, C.; Valentine, J.; Sobel, E.; Atkinson, M. A.; Clare-Salzler, M. J., Increased IFN-alpha-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-alpha production. J Immunol 2014, 193, 1024-1034. Zambon, A.; Sartore, G.; Passera, D.; Francini-Pesenti, F.; Bassi, A.; Basso, C.; Zambon, S.; Manzato, E.; Crepaldi, G., Effects of hypocaloric dietary treatment enriched in oleic acid on LDL and HDL subclass distribution in mildly obese women. J Intern Med 1999, 246, 191-201. Zhao, C.; Su, G.; Wang, X.; Zhang, X.; Guo, S.; Zhao, Y., Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells. Biotechnol Lett 2016, 38, 43-50.zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/96058-
dc.description.abstract苦茶油已被認為具有腸胃保健功效,然而目前苦茶油於免疫調節功效之研究甚少。本實驗利用體外 (in vitro) 及體內 (in vivo) 等實驗模式,評估苦茶油對 RAW 264.7 巨噬細胞株、初代免疫細胞及 BALB/c 小鼠免疫調節功能之影響。實驗結果顯示,苦茶油濃度高於 25 µg/mL 能有效促進巨噬細胞株的吞噬活性、有效抑制 NO 發炎媒介物分泌量及有效抑制IFN-γ 和 IL-6 促發炎激素分泌量之效果。在初代免疫細胞方面,苦茶油濃度高於 25 µg/mL 即可有效促使脾臟細胞增生、有效促進腹腔巨噬細胞之吞噬活性、有效抑制脾臟 IL-1β、IFN-γ (Con A刺激下) 促發炎細胞激素及 NO 發炎媒介物 (LPS刺激下) 分泌量、有效提升脾臟 IL-10及 IL-4 (苦茶油濃度高於 50 µg/mL 及 Con A刺激下) 抗發炎細胞激素分泌量、有效抑制培氏囊細胞 IL-1β (LPS刺激下) 及 IFN-γ 促發炎細胞激素及 NO 發炎媒介物分泌量,以及使脾臟淋巴球傾向CD19+ 之體液免疫分化。動物實驗方面,管餵 2 mL/kg b.w 苦茶油樣品 H 能有效促進脾臟細胞增生活性;管餵 2 mL/kg b.w 苦茶油樣品 H 及 L 均能有效抑制 IFN-γ (LPS刺激下) 及 NO 發炎媒介物 (LPS刺激下) 分泌量、有效促進 IL-10 及 IL-4 (Con A 或 LPS 刺激下) 抗發炎細胞激素分泌量,並同時具有促進體液免疫和細胞免疫 (Con A刺激下) 的效果。總結,苦茶油同時具有促進巨噬細胞吞噬活性、促進體液免疫反應、促進細胞免疫反應、調節 Th1/Th2 細胞激素分泌及抗發炎效果,並且在體外實驗以濃度為 200及 400 µg/mL之苦茶油樣品效果最佳,因此證實苦茶油具免疫調節功效及免疫調節保健品開發之潛力。zh_TW
dc.description.abstractThe beneficial effects of Camellia oil (Camellia oleifera Abel.) on gastrointestinal tract have been recognized; however, the effect of camellia oil on immunomodulatory has not been studied. Therefore, the aim of this study was to evaluate the immunomodulatory effects of camellia oil using an in vitro and in vivo models. In vitro, the results showed that RAW 264.7 macrophage treated with camellia oil (more than 25 µg/mL) significantly increased the phagocytosis activity, and reduced the productions of inflammatory cytokines, including NO, IFN-γ and IL-6. Treatment with camellia oil H (more than 25 µg/mL) significantly increased the proliferation to splenocytes and the phagocytosis activity of macrophage, and reduced the productions of inflammatory cytokines, including NO (with lipopolysaccharide), IL-1β and IFN-γ (with concanavalin A) from splenocytes, and increased the productions of anti-inflammatory cytokines, including IL-10 and IL-4 (camellia oil more than 50 µg/mL and with Con A stimulated) from splenocytes, and reduced the production of inflammatory cytokines, including NO, IL-1β (with LPS) and IFN-γ from Peyer's Patches. In addition, camellia oil could promote the immune regulation toward CD19+ humoral immune response. In vivo, the results showed that oral gavage of BALB/c mice with camellia oil H and L (2 mL/Kg) for 21 days, not only significantly increased the proliferation of splenocytes and the productions of anti-inflammatory cytokines, including IL-10 and IL-4 (with LPS or ConA), and also reduced the production of inflammatory cytokines, including IFN-γ (with LPS) and NO (with LPS). Moreover, camellia oil induced the splenocytes toward humoral and cellular (with ConA) immunity at the same time. In conclusion, camellia oil has the potential to enhance immune function, including increased the phagocytosis by macrophages, humoral immunity and cellular immunity. Camellia oil also could modulate the Th1/Th2 cytokines production, suggesting that this agent can be used for modulation of the immune system and as anti-inflammatory agent. The best effect of camellia oil on immunomodulatory is camellia oil with the concentration of 200 and 400 μg/mL in vitro. Therefore, our results support the possible use of camellia oil as a dietary supplement toward immunomodulation.en_US
dc.description.tableofcontents全文摘要 i Abstract ii 目次 iv 圖次 vi 表次 vii 縮寫表 ix 壹、前言 1 貳、文獻整理 2 一、免疫系統簡介 3 (一)、先天性免疫反應 3 (二)、後天性免疫反應 5 (三)、細胞激素之功能 6 (四)、第一型和第二型 T 輔助型細胞之平衡 8 二、腸道免疫之簡介 12 三、免疫失調之機轉及病症 15 (一)、自身免疫系統之耐受性 15 (二)、自體免疫疾病發生之機轉 16 (三)、免疫失調之疾病 17 四、健康食品現況暨油脂對免疫的影響 19 (ㄧ)、健康食品現況分析 19 (二)、油脂攝取對免疫的影響 20 六、苦茶油之介紹 33 (ㄧ)、油茶樹 33 (二)、苦茶油 34 (三)、苦茶油機能性質 36 七、研究目的 40 八、研究架構 41 參、材料與方法 42 肆、結果 53 一、苦茶油對 RAW264.細胞株免疫指標之影響 53 二、苦茶油對初代免疫細胞免疫指標之影響 55 三、苦茶油對BALB/c 小鼠免疫指標之影響 62 伍、討論 67 陸、結論 76 柒、參考文獻 115zh_TW
dc.language.isozh_TWzh_TW
dc.rights同意授權瀏覽/列印電子全文服務,2020-08-28起公開。zh_TW
dc.subject苦茶油zh_TW
dc.subject初代細胞zh_TW
dc.subject抗發炎zh_TW
dc.subject免疫調節zh_TW
dc.subject體液免疫zh_TW
dc.subjectCamellia oilen_US
dc.subjectprimary cellen_US
dc.subjectanti-inflammationen_US
dc.subjectimmunomodulatoryen_US
dc.subjecthumoral immunityen_US
dc.titleImmunomodulatory and anti-inflammatory effects of camellia oilen_US
dc.title苦茶油之免疫調節及抗發炎功效zh_TW
dc.typethesis and dissertationen_US
dc.date.paperformatopenaccess2020-08-28zh_TW
dc.date.openaccess2020-08-28-
Appears in Collections:食品暨應用生物科技學系
文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.