Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/96287
標題: (1)Synthesis of glycopeptide of β(1→4) diglucosamine (2)Synthesis of protected galactosamine
(1)合成β(1→4)雙葡萄醣胺醣胜肽 (2)合成全保護的半乳醣胺
作者: Yong-Long Syu
許永龍
關鍵字: 醣胜肽
半乳醣胺
glycopeptide
galactosamine
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摘要: The first part of the thesis describes the discovery of glycopeptide and its potential value of imaging probe for tumor angiogenesis. How to synthesize GP is the point of this thesis and this article provides a reaction path way to synthesize diglucosamine and tries to increase the length of the sugar link. We hope to develop a new type drug which can be a selective to tumor cells. The second part of this thesis descrips GD2, GT2, GM1 and Tn agent and provides a deferent way to make the bulding blocks of full protected galatosamine. Using glucosamine as starting material the price of synthesis can be lower.
論文的第一部分在說明醣胜肽的發現以及其潛力價值,如何合成醣胜肽為本論文的重點。本篇提供了一種合成醣胜肽的反應路徑,並希望能夠增加醣的數目,以符合醣胜肽分子的特性,並找出對腫瘤細胞有著良好選擇性的醣胜肽產物。並期望能開發出一新型藥物,能作為藥物載體或能作為正電子發射計算機斷層掃描顯影所需的放射性注射藥物。 第二部分主要作為GD2、GT2、GM1和Tn抗原等藥物分子的建構基石,將較為便宜的葡萄糖胺轉換成價格昂貴的半乳糖胺,並為了合成上述生物分子設計了具有保護基的半乳糖胺。
URI: http://hdl.handle.net/11455/96287
文章公開時間: 10000-01-01
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