請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/96341
標題: Investigation on Aromatic-mediated Domino Rh-Catalyzed Hydroformylation Double Cyclization and Synthetic Studies on Securinega Alkaloid Securinine
關於以芳香環控制之骨牌式銠催化雙環化反應與葉底珠屬植物鹼Securinine之合成研究
作者: Tai-Hung Yang
楊泰泓
關鍵字: 芳香環
骨牌式銠催化雙環化反應
葉底珠屬植物鹼
Rh-Catalyzed Hydroformylation Double Cyclization
Securinine
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摘要: This thesis describes the investigation of aromatic-mediated domino Rh- catalyzed hydroformylation bicyclization, which has been developed for rapid preparation of medicinally-interesting alkaloids. The first part is focused on the scope and limitation study using various substrste, comprising of allylamide, homoallylamide, and 3-butenamide derivatives bearing 3,4-dimethoxybenzene or 3,4,5-trimethoxybenzene moiety. The second part we used furan-mediated domino hydroformylation bicyclization to synthesize Securinine skeleton.
本篇主旨在於探討芳香環控制下的骨牌式銠催化氫甲醯雙環化反應,並應用於含氮雜環生物鹼之合成。第一章節著重在以多取代苯環作為碳親核基團,在不同類型的醯胺基質中進行氫甲醯雙環化反應。第二章節則以四氫苯並呋喃衍生物為親核基團,進行骨牌式銠催化氫甲醯雙環化反應,建構葉底珠屬植物鹼Securinine之骨架。
URI: http://hdl.handle.net/11455/96341
文章公開時間: 2018-08-29
顯示於類別:化學系所

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