Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/98011
標題: 人體維生素D濃度不足與帶狀疱疹後神經痛有關,並與自發性疼痛呈負相關
Hypovitaminosis D is linked to postherpetic neuralgia and inversely associated with spontaneous pain
作者: 林耀聰
Yao-Tsung Lin
關鍵字: 帶狀疱疹
帶狀疱疹後神經痛
維生素D不足
herpes zoster
postherpetic neuralgia
hypovitaminosis D
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摘要: 目的:評估帶狀疱疹後神經痛(postherpetic neuralgia; PHN)患者體內維生素D不足{血清25-羥基維生素D [1,25(OH)2D]的濃度低於30ng/ml}的盛行率以及帶狀疱疹後神經痛與維生素D不足之間的關係。 材料和方法:這是一個回溯性病例對照研究方法,以電腦自動搜尋電子病歷,病例組62人與對照組186人,比例為1:3。病例組為在本院的疼痛門診就診,50歲以上,初次被診斷為帶狀疱疹和/或帶狀疱疹後神經痛,並有檢查血清25(OH)D的患者。對照組為以年齡及性別為配對,搜尋在本院接受健康檢查的健康民眾。搜尋後回溯病歷,紀錄病人相關數據。所得數據依連續變相及類別變相的不同,使用不同的計算方式,來檢視統計結果之間有無差別。所得相關因子再以條件邏輯式回歸分析。另外以皮爾森相關計算衡量組別之間的關係。 結果:疱疹後神經痛患者血中維生素D缺乏的盛行率高於對照組(77.4% vs. 49.5%, p <0.001)。而其引發的自發性疼痛的疼痛程度與血清中維生素D濃度高低呈負相關。 結論:維生素D不足可能在疱疹後神經痛的發生中有重要作用。
Aim: To assess the prevalence of hypovitaminosis D in postherpetic neuralgia (PHN) patients and the relationship between PHN and hypovitaminosis D. Materials and methods: Aretrospective case-control study with a ratio 1:3(62 cases, 186 controls) was conducted. An automatched search was employed for the PHN patients who visited our pain clinic with diagnosed herpes zoster and/or postherpetic neuralgia for the first time, age ≧50 years old and had the examination of serum 25(OH)D were included. Patients who received healthexamination in our hospital were the controls. Medical charts were reviewed and data were recorded and analyzed. The difference ofcontinuousdata between two groups was conducted by Student T test. Chi-square test or Fisher exact test was used for the categoricalvariables. A p value of <0.05 was considered significant. Results:Higher prevalence of hypovitaminosis D was noted in PHN patients compared to that in the controls (77.4%vs. 49.59%, p<0.001). PHN patients with moderate to severe pain had significantly lower serum 25(OH)D concentrations than those with mild pain. Conclusion: Hypovitaminosis D may play an important role in the development of PHN.
URI: http://hdl.handle.net/11455/98011
文章公開時間: 2021-08-22
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