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dc.description.abstract本研究以羧甲基纖維素鈉(Sodium carboxymethyl cellulose;CMCNa)與交聯劑聚乙二醇二縮水甘油醚(Poly(ethylene glycol) diglycidyl ether;PEGDE)製備CMC/PEG 水膠,探討交聯劑分子量及添加量對水膠性質之影響,以 CMC/PEG 包覆親疏水性藥物,不同 pH 值探討其釋放行為及動力學。本研究分為三個部分, 第一部分探討水膠製備條件對於其性質之影響,結果顯示 CMCNa 與 PEGDE 開 環聚合產生醚鍵結構,增加交聯劑 PEGDE 之添加量及分子量,使水膠之熱穩定 性和凝膠分率提高,且平均孔徑和平衡膨潤率降低,結果證實交聯劑使水膠分子 鏈活動性下降、架橋密度與機械性質增加,體外細胞存活率試驗顯示 CMC/PEG 具生物相容性。第二部分為 CMC/PEG 水膠於親水性藥物(Fluorescein sodium salt; FSS)傳輸系統之應用,於不同 pH 值環境下水膠與乾凝膠皆具有緩釋作用,同 時其釋放速率隨交聯劑添加量及分子量增加而下降,其釋放行為符合 Higuchi 動力學模型。第三部分為 CMC/PEG 水膠於疏水性藥物薑黃素(Curcumin;CUR) 傳輸系統之應用,以乳化液提高 CUR 於水相中溶解度達 1600 倍,於不同 pH 值 環境下水膠具有緩釋效果,釋放曲線近零級動力學模型為理想之藥物釋放,研究 結果證實 CMC/PEG 水膠可應用於親疏水性藥物傳輸系統之潛力。zh_TW
dc.description.abstractIn this study, CMC/PEG hydrogels were synthesized from sodium carboxymethyl cellulose (CMCNa) and poly(ethylene glycol) diglycidyl ether (PEGDE) as a crosslinking agent. The effect of molecular weight and ratio of crosslinking agent on the properties of CMC/PEG hydrogel has been investigated. Hydrophilic and hydrophobic drugs loaded into CMC/PEG hydrogel-based drug delivery systems were monitored the release profiles under in different pH values. This dissertation is divided into three parts, the first part is the synthesis and properties of CMC/PEG hydrogel. The results indicate that CMCNa react with PEGDE to form ether bond by ring opening polymerization. Increasing the molar ratio and molecular weight of PEGDE, the results show that increase of thermal stability and gel fraction and decrease of the average pore diameter and equilibrium swelling ratio of CMC/PEG hydrogel. The results indicate that higher crosslink density and lower molecular chain activity increase and mechanical property. In vitro cytotoxicity indicated CMC/PEG hydrogels have good biocompatibility properties. The second part is the study of CMC/PEG hydrogels and xerogels delivery system for a hydrophilic model drug, fluorescein sodium salt (FSS). CMC/PEG hydrogel and xerogel both show the sustained release profile. The release profiles show the release rate of CMC/PEG delivery system with increasing the molar ratio and molecular weight of PEGDE are retarded. FSS release kinetics of CMC/PEG followed the Higuchi model. The third part is the application of hydrophobic drug delivery system. Emulsification technique increases solubility 1600 times of curcumin (CUR) in water phase. CUR shows sustained release property of CMC/PEG hydrogels in different pH value. The release profile of CUR from CMC/PEG hydrogels followed the ideal zero-order model. Those results demonstrated CMC/PEG hydrogels have great potential as hydrophilic and hydrophobic drug delivery systems.en_US
dc.description.tableofcontents摘要 i Abstract ii 目錄 iv 表目次 vii 圖目次 x 第一章、前言 1 第二章、文獻回顧 3 一、水膠之定義及分類 3 二、纖維素基質水膠 10 三、PEG基質水膠 14 四、水膠於控制釋放系統之應用 17 五、乳化作用 26 第三章、纖維素交聯化學水膠之基本性質 29 ㄧ、材料與方法 29 (一) 試驗材料 29 (二) 聚乙二醇交聯羧甲基纖維素水膠之製備 30 (三) CMC/PEG水膠性質分析 32 二、結果與討論 35 (一) CMC/PEG水膠溶液基本性質 35 (二) 流變性 36 (三) FTIR結構分析 42 (四) 熱重分析 47 (五) 水膠SEM型態觀測 51 (六) 凝膠分率 53 (七) 膨潤性質 55 (八) 細胞毒性試驗 58 第四章、聚乙二醇交聯羧甲基纖維素水膠於 親水性藥物傳輸系統之應用 64 一、材料與方法 64 (一) 試驗材料 64 (二) CMC/PEG水膠之製備 64 (三) 包覆FSS之CMC/PEG水膠之製備 65 (四) 藥物濃度及包覆率試驗 65 (五) 藥物釋放試驗 67 (六) 藥物釋放動力學模型 67 二、結果與討論 69 (一) 親水性藥物濃度及包覆率 69 (二) 親水性藥物於中性環境釋放試驗 71 (三) 親水性藥物於鹼性環境釋放試驗 81 (四) 親水性藥物酸性環境釋放試驗 89 (五) 親水性藥物釋放動力學分析 96 第五章、聚乙二醇交聯羧甲基纖維素水膠於 疏水性藥物傳輸系統之應用 104 一、材料與方法 105 (一) 試驗材料 105 (二) CMC/PEG水膠之製備 105 (三) CUR乳化液製備 105 (四) CUR乳化液性質測定 106 (五) 包覆CUR之CMC/PEG水膠之製備 106 (六) 藥物釋放試驗 106 (七) 藥物釋放動力學模型 106 二、結果與討論 107 (一) CUR乳化液性質 107 (二) 疏水性藥物釋放試驗 109 (三) 疏水性藥物釋放動力學分析 114 第六章、結論 118 參考文獻 120zh_TW
dc.subjectCarboxymethyl celluloseen_US
dc.subjectPolyethylene glycolen_US
dc.subjectControlled releaseen_US
dc.subjectHydrophilic drugen_US
dc.subjectHydrophobic drugen_US
dc.titlePreparation of Crosslinked Cellulose-based Hydrogels for Controlled Release of Hydrophilic and Hydrophobic Drugsen_US
dc.typethesis and dissertationen_US
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