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標題: 評估鉻離子對於Olanzapine誘導肥胖雌性大鼠的影響
Evaluation of chromium on olanzapine-induced obesity in female rats
作者: 洪義証
Yi-Jheng Hong
關鍵字: olanzapine

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摘要: 思覺失調症約占全世界人口1%的精神疾病。由於錐體外路徑症候群(EPS)副作用的發生率較低,因此第二代抗精神病藥物常作為思覺失調症患者的第一線治療藥物。然而,使用這類藥物經常伴隨的肥胖和胰島素相關的代謝紊亂,像是血脂異常和第二型糖尿病的產生,影響了這些藥物的臨床應用。微量元素在調節身體的正常代謝具有重要價值,因為它們與許多酵素及荷爾蒙之間具有相互作用。鉻是碳水化合物、蛋白質和脂肪正常代謝所需的一種微量元素。先前的一些研究表明,鉻能夠提高了胰島素的活性,而經由膳食補充鉻可以調節並改善葡萄糖代謝。鉻還能抑制食慾,增加熱量產生和維持體內衡定。因此本實驗目的是為了解olanzapine對大鼠體內鉻離子分佈的影響和鉻離子補充是否可以改善olanzapine誘導的肥胖雌性大鼠。在這研究中,利用Sprague-Dawley (SD) 雌性大鼠分為對照組和olanzapine組。實驗進行14天後將動物犧牲,取出血液,尿液,相關器官並進行分析。實驗結果表明, olanzapine與對照組相比體重顯著增加。動物的血糖,胰島素,脂質和發炎細胞激素瘦素和介白質素-6也呈上升趨勢。在AMPK訊號傳遞路徑中,olanzapine與對照組相比發現AMPK和ACC蛋白質磷酸化減少。在肝臟和白色脂肪組織中微量元素鉻含量也顯著低於對照組。我們還分析了鉻離子補充劑對olanzapine誘導代謝異常動物的影響。結果表明,補充鉻可顯著改善體重、血糖、胰島素、脂質、發炎性細胞激素和AMPK訊號傳遞路徑。我們的研究結果表明,olanzapine治療後體重明顯增加,並可能存在代謝症候群。補充鉻離子能有效改善olanzapine誘導肥胖代謝異常。
Schizophrenia is a mental illness that affects one percent of people worldwide. Due to their lower incidences of extrapyramidal symptoms (EPS) side effects, second-generation antipsychotics (SGAs) are the first line of treatment for those with schizophrenia. However, the accompanying obesity and insulin-related metabolic disorders including dyslipidemia, and type 2 diabetes hinder their clinical application. Trace elements are of great value in regulation of normal body metabolism, as they interact with many enzymes and hormones. Chromium (Cr) is one of trace elements required for the normal metabolism of carbohydrate, protein and fat. Previous research revealed that chromium raises the activity of insulin, and dietary supplementation with chromium has regulated improvements in glucose metabolism. Chromium also suppress the appetite and increase heat production energy and homeostasis. We aimed to identify empirical research on Cr distribution and Cr supplement may improve metabolic syndrome on olanzapine-induced obesity rats. Here, the experimental design Sprague-Dawley (SD) female rats were divided into groups of control and olanzapine group. These female rats were sacrificed 14 days after the experiment, and remove the blood, urine, related organs and analyze. The experimental results showed that olanzapine was significantly increased the body weight compared to the control. The blood glucose, insulin, lipids, and inflammatory cytokines leptin and IL-6 in olanzapine also showed an upward trend. Olanzapine decreased in AMPK and ACC compared with control in AMPK pathway. Analysis of trace elements, Cr had a significant decrease in olanzapine in the liver and white adipose tissue compared with control. We also analyzed the effect of Cr supplement on olanzapine induced metabolic disorders animal. The results showed that chromium supplementation significantly ameliorate in body weight, blood glucose, insulin, lipids, inflammatory cytokines and AMPK pathway. According to the above results, our findings showed that after the treatment of olanzapine, the body weight increased significantly, and there may be a metabolic syndrome. And chromium have been displayed for improving metabolic disorders on olanzapine-induced obesity in female rats.
文章公開時間: 2021-08-31
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