Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99078
標題: Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication
作者: Jhang, Jhih-Jia
Lin, Jia-Hong
Yen, Gow-Chin
顏國欽
關鍵字: IL-1β
NLRP3
gout
monosodium urate
phytochemicals
Animals
Antioxidants
Crystallization
Diet
Flavonoids
Gout
Humans
Inflammasomes
Interleukin-1beta
NLR Family, Pyrin Domain-Containing 3 Protein
Phytochemicals
Phytotherapy
Resveratrol
Stilbenes
Uric Acid
摘要: Gouty arthritis is characterized by the precipitation of monosodium urate (MSU) crystals in the joint. Pro-inflammatory cytokine IL-1β is a critical manifestation in response to MSU crystals attack. IL-1β secretion is dependent on the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Abnormal activation of the NLRP inflammasome is related to cellular oxidative stress. However, recent studies have illustrated that phytochemicals with potent antioxidant activity exert inhibitory effects on NLRP3 inflammasome-mediated diseases. This review focuses on the current findings of studies on the NLRP3 inflammasome and the proposed mechanisms that MSU crystals trigger inflammation via activation of the NLRP3 inflammasome. We also summarized the potential use of phytochemicals on NLRP3 inflammasome-mediated diseases, suggesting that phytochemicals can further prevent acute gout attack.
URI: http://hdl.handle.net/11455/99078
文章連結: https://www.ncbi.nlm.nih.gov/pubmed/29293001
Appears in Collections:食品暨應用生物科技學系

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