Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99080
標題: Effect of Phyllanthus emblica L. fruit on methionine and choline-deficiency diet-induced nonalcoholic steatohepatitis
作者: Tung, Yu-Tang
Huang, Cheng-Ze
Lin, Jia-Hong
Yen, Gow-Chin
顏國欽
關鍵字: Lipid peroxidation
Methionine and choline-deficiency diet
Nonalcoholic steatohepatitis
Oxidative stress
Phyllanthus emblica
Animals
Choline
Diet
Fruit
Humans
Interleukin-1beta
Lipid Peroxidation
Liver
Male
Methionine
Mice
Mice, Inbred C57BL
Non-alcoholic Fatty Liver Disease
Phyllanthus emblica
Plant Extracts
Tumor Necrosis Factor-alpha
摘要: Phyllanthus emblica L. fruit contains abundant bioactive components and exhibits a variety of biological activities. In this study, the hepatoprotective effect of water extract of P. emblica (WEPE) on nonalcoholic steatohepatitis (NASH) was evaluated. C57BL/6 mice were fed methionine and choline-deficiency diet (MCD diet) for 4 or 8 weeks to induce NASH. Results showed that administration of WEPE could significantly reduce serum AST and ALT as compared to MCD diet-alone group. Administration of WEPE could significantly decrease lipid peroxidation and CYP2E1 mRNA expression, and elevate the antioxidant activities in mice livers. In addition, administration of WEPE after 8 weeks could significantly decrease the mRNA expressions of TNF-α and IL-1β in mice livers, but have less improving effect of hepatic steatosis and mononuclear cell infiltration. Taken together, MCD diet might cause serious hepatic steatosis and mild inflammation in mice livers, but administration of WEPE could ameliorate the rapid progression of NASH.
URI: http://hdl.handle.net/11455/99080
ISSN: 1021-9498
Appears in Collections:食品暨應用生物科技學系

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.