Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99107
標題: Synthesis and Bioassay of Neurogenically Potent Gangliosides DSG-A, Hp-s1 and Their Analogues
作者: Shelke, Ganesh B
Lih, Yu-Hsuan
Liao, Ying-Ju
Liang, Chih-Wu
Kuo, Tzer-Min
Ko, Ying-Chin
Luo, Shun-Yuan
羅順原
關鍵字: Ganglioside Hp-s1
IL-17A
SH-SY5Y cells
analogues
hydrophobicity
neurogenic activity
Cell Line
G(M1) Ganglioside
Gangliosides
Humans
Neurites
Neuroblastoma
Neurogenesis
Tumor Cells, Cultured
Biological Assay
摘要: In the search of a potent candidate for neurotherapy, we designed and synthesized various analogues of ganglioside Hp-s1. The modification includes the change in hydrophobicity by varying the carbon chain length, altering the number of hydrogen bonds, and replacing the anomeric atom. The chemical synthesis was carried out by using various methods and discussed in details. The neuritogenic activities of these analogues are confirmed in a human neuroblastoma cell line SH-SY5Y. A higher activity of ganglioside Hp-s1 analogue on IL-17A transcript upregulation than ganglioside Hp-s1 was found.
URI: http://hdl.handle.net/11455/99107
文章連結: https://www.ncbi.nlm.nih.gov/pubmed/29558805
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