Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99107
DC FieldValueLanguage
dc.contributor.authorShelke, Ganesh Bzh_TW
dc.contributor.authorLih, Yu-Hsuanzh_TW
dc.contributor.authorLiao, Ying-Juzh_TW
dc.contributor.authorLiang, Chih-Wuzh_TW
dc.contributor.authorKuo, Tzer-Minzh_TW
dc.contributor.authorKo, Ying-Chinzh_TW
dc.contributor.authorLuo, Shun-Yuanzh_TW
dc.contributor.author羅順原zh_TW
dc.date2018-
dc.date.accessioned2019-10-02T06:09:45Z-
dc.date.available2019-10-02T06:09:45Z-
dc.identifier.urihttp://hdl.handle.net/11455/99107-
dc.description.abstractIn the search of a potent candidate for neurotherapy, we designed and synthesized various analogues of ganglioside Hp-s1. The modification includes the change in hydrophobicity by varying the carbon chain length, altering the number of hydrogen bonds, and replacing the anomeric atom. The chemical synthesis was carried out by using various methods and discussed in details. The neuritogenic activities of these analogues are confirmed in a human neuroblastoma cell line SH-SY5Y. A higher activity of ganglioside Hp-s1 analogue on IL-17A transcript upregulation than ganglioside Hp-s1 was found.zh_TW
dc.language.isoenzh_TW
dc.relationACS chemical neuroscience, Volume 9, Issue 6, Page(s) 1264-1268.zh_TW
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/29558805zh_TW
dc.subjectGanglioside Hp-s1zh_TW
dc.subjectIL-17Azh_TW
dc.subjectSH-SY5Y cellszh_TW
dc.subjectanalogueszh_TW
dc.subjecthydrophobicityzh_TW
dc.subjectneurogenic activityzh_TW
dc.subjectCell Linezh_TW
dc.subjectG(M1) Gangliosidezh_TW
dc.subjectGangliosideszh_TW
dc.subjectHumanszh_TW
dc.subjectNeuriteszh_TW
dc.subjectNeuroblastomazh_TW
dc.subjectNeurogenesiszh_TW
dc.subjectTumor Cells, Culturedzh_TW
dc.subjectBiological Assayzh_TW
dc.titleSynthesis and Bioassay of Neurogenically Potent Gangliosides DSG-A, Hp-s1 and Their Analogueszh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/acschemneuro.8b00055zh_TW
dc.awards2018zh_TW
Appears in Collections:化學系所
文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.