Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99334
標題: Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells
作者: Chen, Huei-Yu
Islam, Atikul
Yuan, Tien-Ming
Chen, Shi-Wen
Liu, Pei-Fen
Chueh, Pin Ju
闕斌如
關鍵字: Apoptosis
Oxaliplatin
ROS
Sirtuin 1 (SIRT1)
Tumor-associated NADH oxidase (tNOX or ENOX2)
p53
Cell Line, Tumor
Colonic Neoplasms
Humans
NADH, NADPH Oxidoreductases
Oxaliplatin
Reactive Oxygen Species
Transfection
Tumor Suppressor Protein p53
摘要: Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward oxaliplatin due to yet-unknown underlying mechanisms. We recently established that oxaliplatin also exert its anti-cancer activity in gastric cancer cell lines by targeting tumor-associated NADH oxidase (tNOX), attenuate NAD+ generation and reduce NAD+-dependent sirtuin 1 (SIRT1) deacetylase activity, which in turn enhances p53 acetylation and apoptosis.
URI: http://hdl.handle.net/11455/99334
Appears in Collections:生醫工程研究所

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