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dc.contributor.authorZi-Jun Liuzh_TW
dc.contributor.authorShu-Ching Linzh_TW
dc.contributor.authorPei-Yuan Leezh_TW
dc.contributor.authorYing-Ting Linzh_TW
dc.contributor.authorZi-Lun Laizh_TW
dc.contributor.authorCheng-Chung Changzh_TW
dc.contributor.authorGou-Jen Wangzh_TW
dc.description.abstractThis study proposes to develop a dual-acting antibacterial film of porous chitosan (Cs) embedded with small molecular compound, which possesses photosensitive characteristics with bactericidal efficacy, to promote the accelerated recovery of infectious wounds. The Cs/small molecular compound (Cs-cpd.2) dressing was prepared using the freeze-drying method. Characterization of the synthesized Cs-cpd.2 indicated that it has high porosity and moisture absorption effect, hence enhancing the absorption of wound exudate. Experimental results showed that Cs-cpd.2 dressing has good bactericidal and bacteriostatic effects on Staphylococcus aureus under visible-light irradiation and has antibacterial effect in the dark. It was also found that the small molecular compound does not have cytotoxicity at a dose of 0–5 μM. Furthermore, Cs-cpd.2 that contained small molecular compound with a concentration of 0.3–1 μM has positive effect on both the cell viability rate and cell proliferation rate of human fibroblast CG1639. Cs-cpd.2 can significantly promote cell proliferation when the small molecular compound and the basic fibroblast growth factor bFGF were added together. Therefore, the proposed Cs-cpd.2 dressing is feasible for photodynamic therapy (PDT) and clinical wound dressing applications.zh_TW
dc.subjectDual-acting antibacterial filmzh_TW
dc.subjectporous chitosan/small molecular compoundzh_TW
dc.subjectbactericidal and bacteriostatic effectszh_TW
dc.titleDual-acting antibacterial porous chitosan film embedded with a photosensitizerzh_TW
dc.typejournal articlezh_TW
item.openairetypejournal article-
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