Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/100416
標題: Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice
作者: Shih-Yi Lin 
Ching-Ping Yang 
Ya-Yu Wang 
Chiao-Wan Hsiao 
Wen-Ying Chen 
Su-Lan Liao 
Yu-Li Lo 
Yih-Hsin Chang 
Chen-Jee Hong 
Chun-Jung Chen 
關鍵字: IL-4;adiposity;inflammation;leptin;obesity
摘要: 
Obesity is a metabolic disorder that results from complex interactions between genetic predisposition and dietary factors. Interleukin-4 (IL-4), besides its role in immunity, has metabolic effects on insulin efficacy. We studied the effects of IL-4 on metabolic abnormalities in a mice model of obesity involving leptin deficiency and leptin resistance. Leptin-deficient 145E and leptin-resistant high-fat diet (HFD) mice showed lower levels of circulating IL-4. 145E and HFD mice showed a number of abnormalities: Obesity, hyperglycemia, hyperinsulinemia, insulin resistance, dyslipidemia, liver injury, and adiposity with concurrent inflammation, decreases in Akt, signal transducer and activator of transcription 3 (STAT3), and STAT6 phosphorylation in the hypothalamus, liver, and epididymal fat. Independent of leptin-deficient obesity and dietary obesity, a course of 8-week IL-4 supplementation improved obesity and impairment in Akt, STAT3, and STAT6 signaling. Amelioration of cytokine expression, despite variable extents, was closely linked with the actions of IL-4. Additionally, the browning of white adipocytes by IL-4 was found in epididymal white adipose tissues and 3T3-L1 preadipocytes. Chronic exercise, weight management, and probiotics are recommended to overweight patients and IL-4 signaling is associated with clinical improvement. Thus, IL-4 could be a metabolic regulator and antiobesity candidate for the treatment of obesity and its complications.
URI: http://hdl.handle.net/11455/100416
Appears in Collections:獸醫學系所

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