Copper-catalyzed cross-coupling reaction of thiols with aryl halides

Abstract

A combination of CuI with oxalic diamide is a powerful catalytic system for cross-coupling reaction of thiols with aryl bromides and chlorides. It is important to note that unactivated aryl chorides are coupled smoothly with aryl- and alkyl thiols to give the corresponding thioethers in good to excellent yields for the first time.