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Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/12913
標題: 基質金屬蛋白酵素2及9在罹患淋巴瘤犬隻血清中的濃度改變
Altered levels of serum matrix metalloproteinase 2 and 9 in lymphoma-affected dogs
作者: 許如瑩
Hsu, Ju-Ying
關鍵字: matrix metalloproteinase;基質金屬蛋白酵素;lymphoma;淋巴瘤
出版社: 獸醫學系暨研究所
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摘要: 
基質金屬蛋白酵素2及9(MMP-2和MMP-9)在人類的實質固態瘤(solid tumor)中被認為會影響腫瘤細胞的移動、侵犯、轉移和血管新生作用。然而由於明膠酶(gelatinase)相關因子的複雜度，淋巴瘤亞型的多樣性以及較少犬隻相關研究，使明膠酶在犬隻預後評估的價值上仍不明確。因此，此實驗著重在釐清明膠酶和犬隻淋巴瘤間的關係。
在化療前和化療後的復診時收集罹患淋巴瘤犬隻的血清樣本，用明膠酶圖譜分析(gelatin zymography)偵測基質金屬蛋白酵素2及9的濃度。結果顯示，基質金屬蛋白酵素9的濃度在罹患淋巴瘤的犬隻中上升，且在達到完全消退的治療後下降。在基質金屬蛋白酵素2方面，健康對照組、罹患淋巴瘤組和治療中的濃度之間相比都沒有差異。且基質金屬蛋白酵素2及9的濃度在T細胞淋巴瘤比預後較佳的B細胞淋巴瘤高。
此實驗提出基質金屬蛋白酵素9的濃度可以做為犬隻淋巴瘤的預後評估因子，而基質金屬蛋白酵素2則在某些淋巴瘤亞型中扮演較輕的腳色。但因在病患特徵的結果上多變異和一些研究之間的差異，使未來重點放在更多且更大量的樣本研究上。

Gelatinases (MMP-2 and MMP-9) are thought to affect migration, invasion, metastasis and angiogenesis in human solid tumor. However, due to the complex gelatinase-associated factors, diversity of lymphoma subtypes and few researches of canine, the prognostic value of gelatinases in canine lymphoma remains equivocal. Thus this study focuses on clarifying the relation between gelatinases and canine lymphoma.
Serum samples of lymphoma-affected dogs were collected before and after chemotherapy at follow-ups, then gelatin zymography was used to detect the levels of MMP-2 and MMP-9. The results suggest that MMP-9 levels increases in lymphoma-affected dogs and decreases after a complete response is achieved; there are no variations of MMP-2 levels between healthy control, lymphoma-affected dogs and levels during treatment. Both MMP-2 and MMP-9 levels are higher in T-cell lymphoma than B-cell lymphoma patients which have better prognosis.
This study suggests that MMP-9 could be a prognostic factor of canine lymphoma and MMP-2 may play a minor role in some parts of lymphoma subtypes. But variable results of patient characteristics and some differences between studies make us put an emphasis on more studies and larger sample cases in the future.
URI: http://hdl.handle.net/11455/12913
其他識別: U0005-1306201223255500
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