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Metabolic effects of leucine supplement in olanzapine induced obesity in C57BL/6J Narl mice
|關鍵字:||Metabolic syndrome;白胺酸;leucine;olanzapine;obesity;奧氮平;代謝症候群;肥胖||出版社:||獸醫學系暨研究所||引用:||1. Abraham RT. Identification of TOR signaling complexes: more TORC for the cell growth engine. Cell 2002;111:9-12. 2. Albaugh VL, Vary TC, Ilkayeva O, Wenner BR, Maresca KP, Joyal JL, Breazeale S, Elich TD, Lang CH, Lynch CJ . Atypical Antipsychotics Rapidly and Inappropriately Switch Peripheral Fuel Utilization to Lipids, Impairing Metabolic Flexibility in Rodents. Schizophr Bull 2010. 3. Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 1999;156:1686-1696. 4. Ananth J, Parameswaran S, Gunatilake S. Side effects of atypical antipsychotic drugs. Curr Pharm Des 2004;10:2219-2229. 5. Bhana N, Perry CM. Olanzapine: a review of its use in the treatment of bipolar I disorder. CNS Drugs 2001;15:871-904. 6. Boyda HN, Procyshyn RM, Tse L, Wong D, Pang CC, Honer WG, Barr AM. 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Effect of dietary protein on translation initiation in rat skeletal muscle and liver. Am J Physiol 1998;275:E814-820. 53. Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 2007;56:1647-1654.||摘要:||
Metabolic adverse effect is one of the most serious side effects associated with the use of atypical antipsychotics. Some investigators have suggested that some beneficial effects of high protein intake, such as preventing weight gain and promoting loss of body fat, might be attributed to the higher comsumption of branched-chain amino acids (BCAAs), like leucine (Leu). However, it is vague about the anti-obesity effect of leucine in animals treated with antipsychotics. Thus this study investigated the effects of leucine supplement on body weight and lipid metabolism in female C57BL/6JNarl mice treated by olanzapine (Olz). Mice were divided into four groups: olanzapine group (3 mg/kg/day), leucine supplement group (2%water/vol L-leucine), olanzapine combined leucine supplement group and control group. Seven-weeks treatments with olanzapine significantly increased body weight gain and hepatic triglycerides levels that compared to the control group (P < 0.05). However, there was no statistically different for body weight between olanzapine and olanzapine treated with leucine group. Western blotting analysis showed that the expression of FAS and SCD-1 (component of fat synthesis system) were not statistically different among all tested groups. These results suggest that olanzapine exerts some metabolic effects and this leads to increase the accumulation of body weight. However, leucine supplement was not observed to reverse obesity that induced by olanzapine in mice.
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