Please use this identifier to cite or link to this item:
Effect of Exercise and Beta-adrenergic Drugs on Blood Glucose and Hepatic Chromium Levels
|關鍵字:||exercise;運動;beta-adrenergic drugs;blood glucose;chromium;beta腎上腺素藥物;血糖;鉻元素||出版社:||獸醫學系暨研究所||引用:||方進隆。（1997）。教師體適能指導手冊。國立台灣師範大學學校教育與發展中心主編。 行政院衛生署。(2002)。衛生統計（二）生命統計 台北行政院衛生署。 陳國群。(1997)。最新糖尿病精要。藝軒圖書出版社，台北。 Adams, H. R. (1995a) Adrenergic agonists and antagonists. In Veterinary Pharmacology and Therapeutics. 7th ed. Iowa State University Press. USA. pp.87-113. Adams, H. R. (1995b) Drugs acting on the autonomic and somatic nervous systems. In Veterinary Pharmacology and Therapeutics. 7th ed. Iowa State University Press. USA. pp.65-86. Ahima, R. S., and J. S. Flier. (2000) Adipose tissue as an endocrine organ. Trends Endocrinol Metab. 11: 327-332. Ahlborg G, Felig P, Hagenfeldt L, Hendler R, Wahren J. (1974) Substrate turnover during prolonged exercise in man: splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest 53: 1080-1090. Ahlquist RP. (1948) A study of the adrenotropic receptors. Am J Physiol 153: 586-590. American Diabetes Association. (2002) Diabetes mellitus and exercise. Diabetes Care. 25: s64-68. Anderson RA. (1993) Recent advances in the clinical and biochemical effects of chromium deficiency. In: Essential and Toxic Elements in Human Health and Disease: An Update, (Prasad, A. S., ed.). Wiley Liss, New York, USA. pp. 221–234. Anderson RA. (1995) Chromium, glucose tolerance, diabetes and lipid metabolism. J Advancement Med. 8: 37–49. Anderson RA, Bryden NA, Polansky MM, Reisner S. (1990) Urinary chromium excretion and insulinogenic properties of carbohydrates. Am J Clin Nutr 51: 864-868. Anderson RA, Kozlovsky AS. (1985) Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am J Clin Nutri. 41: 768-771. Anderson RA, Mertz W. (1977) Glucose tolerance factor: an essential dietary agent. Trends Biochem Sci. 2: 277-279. Anderson RA, Polansky MM, Bryden NA, Roginski EE, Patterson KY, Reamer DC. (1982) Effect of exercise (running) on serum glucose, insulin, glucagon, and chromium excretion. Diabetes 31: 212–216. Anderson RA, Polansky MM, Bryden NA, Bhatnena SJ, Canary JJ. (1987) Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia. Metabolism. 36: 351-355. Baldwin, S. A. (1993) Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins. Biochim Biophys Acta. 1154: 17-49. Barnard RJ, Jung T, Inkeles SB. (1994) Diet and exercise in the treatment of NIDDM. The need for early emphasis. Diabetes Care. 17: 1469-1472. Benn JJ, Brown PM, Beckwith LJ, Farebrother M, Sonksen PH. (1992) Glucose turnover in type I diabetic subjects during exercise. Effect of selective and nonselective beta-blockade and insulin withdrawal. Diabetes Care 15: 1721-1726. Blair SN, Kohl HW 3rd, Paffenbarger RS , Clark DG, Cooper KH, Gibbons LW. (1989) Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 262: 2395-2401. Bouchard C, Despre JP. (1995) Physical activity and health: Atherosclerotic, metabolic, and hypertension disease. Res Q 66: 268-275. Bouchard C, Shephard RJ, Stephens T. (1994) Physical activity, fitness, and health. International Proceedings and Conference Statement. Champion, IL: Human Kinetics. Bray GA, York DA. (1979) Hypothalamic and genetic obesity in experimental animals: an automonia and endocrine hypothesis. Physiol Rev. 59: 719-809. Burcelin R, Crivelli V, Dacosta A, Roy-Tirelli A, Thorens B. (2002) Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. Am J Physiol Endocrinol Metab. 282: E834-842. Buren, J., H. X. Liu. J. Jesen, and J. W. Eriksson. (2002) Dexamethasone impairs insulin signaling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol. 146: 419-429. Chakravarthy MV, Booth FW. (2004) Eating, exercise, and “thrifty” genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases. J Appl Physiol 96: 3-10. Chan TM, Blackmore PF, Steiner KE, Exton JH. (1979) Effects of adrenalectomy on hormone action on hepatic glucose metabolism. J Biol Chem. 254: 2428-2433. Cheatham B, Kahn CR. (1995) Insulin action and the insulin signaling network. Endocr Rev. 16: 117-142. Coker RH, Krishna MG, Lacy DB, Bracy DP, Wasserman DH. (1997) Role of hepatic alpha and beta adrenergic receptor stimulation on hepatic glucose production during heavy exercise. Am J Physiol Endocrinol Metab. 273: E831-E838. Coker RH, Lacy DB, Williams PE, Wasserman DH. (2000) Hepatic alpha- and beta-adrenergic receptors are not essential for the increase in Ra during exercise in diabetes. Am J Physiol Endocrinol Metab. 278: E444-451. Coltidz, G. A., et al. (1990) Weight as a risk factor for clinical diabetes in women. Am J Epidemiol. 132 : 501-513. Darcye J, Graydon S, Alan Martin, Andrew Ignaszewski, Hugh D, Jiri J.（2003） Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care. 26: 2977-2982. Davidson VL, Sittman DB. (1999) Biochemistry. Lippincott Williams and Wilkins. pp. 333-338. Davis CM, Vincent JB. (1997) Isolation and characterization of a biologically active chromium oligopeptide from bovine liver. Arch Bichem Biophys. 339: 335-343. Davis CM, Vincent JB. (1997) Chromium oligopeptide activates insulin receptor tyrosine kinase activity. Biochemistry. 36: 4382-4385. Davis-Whitenack ML, Adeleye BO, Rolf LL, Stoecker BJ. (1996) Biliary excretion of 51 chromium in bile-duck cannulated rats. Nutr Res. 16: 1009-1015. Deacon SP, Karunanayake A, Barnett D. (1977) Acebutolol, atenolol, and propranolol and metabolic responses to acute hypoglycaemia in diabetics. Br Med J. 12:1255-1257. DeFronzo RA, Bonadonna RC, Ferrannini E. (1992) Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15: 318-68. DeFronzo RA, Ferrannini E, Sato Y, Felig P, Wahren J. (1981) Synergistic Interaction between Exercise and Insulin on Peripheral Glucose Uptake. J Clin Invest. 68: 1468-1474. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237: 214-223. Despres J-P & Marette A. (1994) Relation of components of insulin resistance syndrome to coronary disease risk. Curr Opin Lipidol 5: 274-289. Ding W, Chai Z, Duan P, Feng W, Qian Q. (1998) Serum and urine chromium concentrations in elderly diabetes. Biol Trace Elem Res. 63: 231-237. Ferraro DeFronzo RA, Ferrannini E. (1991) Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease . Diabetes Care. 14: 173-194. Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL. (1998) Overweight and Obesity in the United States: prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord. 22: 39-47. Fraze E, Donner CC, Swislocki AL, Chiou YA, Chen YD, Reaven GM. (1985) Ambient plasma free fatty acid concentrations in noninsulin-dependent diabetes mellitus: evidence for insulin resistance. J Clin Endocrinol Metab 61: 807-11. Fridlyand LE, Philipson LH. (2004) Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes. 53: 1942-1948. Fripp RIH. (1987) Effect of resistive training on plasma lipid and lipoprotein levels in male adolescents. J Pediatr. l: 926-934. Hargreaves M. (1997) Interactions between muscle glycogen and blood glucose during exercise. Exerc Sport Sci Rev. 25: 21-39. Harvey RA, Champe PC. (1997) Lippincott''s Illustrated Reviews Pharmacology. Lippincott Williams and Wilkins. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS. (1991) Physical activity and reduced occurrence of noninsulin-dependent diabetes mellitus. N Engl J Med 325: 147-152. Henriksen EJ. (2002) Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol. 93(2): 788-796. Hunt DG, Ding Z, Ivy JL. (2002) Propranolol prevents epinephrine from limiting insulin-stimulated muscle glucose uptake during contraction. J Appl Physiol. 93: 697-704. Ivy JL, Kuo CH. (1998) Regulation of GLUT-4 protein expression and glycogen storage after prolonged exercise. Acta Physiologica Scandinavica. 165: 193-201. Ivy JL, Sherman WM, Cutler CL, Katz A. (1986) Exercise and diet reduce muscle insulin resistance in obese Zucker rat. Am J Physiol Endocrinol Metab. 251: 299-305. Ivy JL. (1997) Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports Med. 24: 321-336. Jensen MD, Haymond MW, Rizza RA, Cryer PE, Miles JM. (1989) Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest. 83: 1168–73. Kelley DE, Goodpaster BH. (1999) Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc. 31: S619-623. Khan S and Rupp J (1995). The effect of exercise conditioning, diet and drugtherapy on glycosylated hemoglobin levels in type 2 (NIDDM) diabetics. J Sports Med Phys Fitness. 35: 281-288. King AC, Tribble DD. (1991) The role of exercise in weight regulation in nonathletes. Sports Med.. 11: 331-349. Kivisto VA, Yki-Jarvinen H and Defronzo RA (1986) Physical training andinsulin sensitivity. Diabetes Metab Rev. 14: 445-481. Kjaer M. (1998) Hepatic glucose production during exercise. Adv Exp Med Biol. 441: 117-127. Klesges RC, Eck LH, Isbell TR. (1991) Physical activity, body composition, and blood pressure: A multi-method approach. Med Sci Sports Exerc. 23: 759-765. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. (2002) Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393-403. Kopelman PG, Grace C. (2004) New thoughts on managing obesity. Gut. 53: 1044-1053. Kopelman PG. (2000) Obesity as a medical problem. Nature. 404: 635-643. Koster JC, Permutt MA, Nichols CG. (2005) Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection. Diabetes. 54: 3065-3072. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH. (1991) Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40: 1397-403. Kriska AM, Blair SN, Preeira MA. (1994) The potential role of physical activity in the prevention of noninsulin dependent diabetes nellitus: The epidemiological evidence in Holloszy. Exerc Sports Sci Rev. 22: 121-143. Kujala UM, Kaprio J, Sarna S, Koskenvuo M. (1998) Relationship of leisure-time physical activity and mortality: the Finnish twin cohort. JAMA 279: 440-444. Kuo CH. Hunt DG. Ding Z. Ivy JL.（1999）Effect of carbohydrate supplementation on postexercise GLUT-4 protein expression in skeletal muscle. J Appl Physiol. 87: 2290-2295. Ladu MJ. Kapsas H. Palmer WK.（1991）Regulation of lipoprotein lipase in muscle and adipose tissue during exercise. J Appli Physi. 71: 404-409 . Lerman I, Harrison BC, Freeman K, Hewett TE, Allen DL, Robbins J, Leinwand LA. (2002) Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. J Appl Physiol. 92: 2245-2255. Lukaski HC. (1999) Chromium as a supplement. Annu Rev Nutr. 19: 279-302. Maki T. (1989) Density and functioning of human lymphocytic beta adrenergic receptors during prolonged physical exercise. Acta Physiol Scand. 136: 569-574. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH. (1992) A prospective study of exercise and incidence of diabetes among US male physicians. JAMA 268: 63-67. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, Speizer FE. (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338: 774-778. Mertz W. (1993) Chromium in human nutrition: a review. J Nutr 123: 626-633. Mertz W. (1969) Chromium occurrence and function in biological systems. Physiol Rev 49: 163-239. Mertz W. (1975) Effects and metabolism of glucose tolerance factor. Nutr Rev. 33: 129-135. Mertz W, Toepfer EW, Roginski EE, Anderson RA. (1974) Present knowledge of the role of chromium. Fed Proc. 33: 2275-2280. Moreno-Aliaga MJ, Stanhope KL, Havel PJ. (2001) Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3t3-I1 adipocytes. Biochem Biophys Res Commun. 283: 544-548. Morris BW, Gray TA, MacNeil S. (1993) Glucose-dependent uptake of chromium in human and rat insulin-sensitive tissues. Clin Chem. 84: 477-482. Must A, Spandano J, Coakley EH. (1999) The disease burden associated with overweight and obesiy. JAMA. 282: 1523-1529. Nelson DL, Cox MM. (2000) Lehninger principles of biochemistry. Worth Publishers. pp. 138-145. Nielsen FH (1994) Chromium. In: Shils ME, Olson JA, Shike M.,eds.Mondern nutrition in health and disease. Philadelphia: Lea and Febiger. 264-268. Ohman EM, Butler J, Kelly J, Horgan J, O’Malley K. (1987) beta-adrenoceptor adaptation to endurance training. J Cardiovas Pharmacol. 10: 728-731. Ortmeyer HK, Bodkin NL, Hansen BC. (1993) Insulin-mediated glycogen synthase activity in muscle of spontaneously insulin-resistant and diabetic monkey. Am J Physiol. 334: 292-295. Pessin, J. E., and A. R. Saltiel. (2000) Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest. 106: 165-169. Potter DE, Ellis S. (1975) Isoproterenol- and epinephrine-induced changes in blood glucose and tissue glycogen levels in normal and diabetic rats: the influence of alteration in endogenous insulin levels and state of nourishment. J Pharmacol Exp Ther. 193: 576-584. Reaven GM. (1988) Role of insulin resistance in human disease. Diabetes 37: 1595-1607. Reaven GM. (1992) The role of insulin resistance and hyperinsulinemia in coronary heart disease. Metabolism. 41: 16-19. Reaven PD, Barrett-Connor E, Edelstein S. (1991) Relation between leisure time physical activity and blood pressure in older women. Circulation. 83: 559-665. Roberts AC, Reeves JT, Butterfield GE, Mazzeo RS, Sutton JR, Wolfel EE, Brooks GA. (1996) Altitude and beta blockade augment glucose utilization during submaximal exercise. J Appl Physiol 80: 605-615. Rossmeisl M, Rim JS, Koza RA, Kozak LP. (2003) Variation in type 2 diabetes-related traits in mouse strains susceptible to diet-induced obesity. Diabetes 52: 1958-1966. Saltiel AR, Kahn CR. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 414: 799-806. Schwarz K, Mertz W. (1959) ChromiumⅢ and the glucose tolerance factor. Arch Biochem Biophys 85: 292-295. Shepherd PR, Barbara BK. (1999) Glucose transporters and insulin action. N Engl J Med. 341: 248-257. Simonson DC, Koivisto V, Sherwin RS, Ferrannini E, Hendler R, Juhlin-Dannfelt A, DeFronzo RA. (1984) Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics. J Clin Invest 73: 1648-1658. Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn CM, Rebuffe-Scrive M. (1995) Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism. 44: 645-651. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. (1988) Diet-induced typeⅡ diabetes in C57BL/6J mice. Diabetes. 37: 1163-1167. Surwit RS, Seldin MF, Kuhn CM, Cochrane C, Feinglos MN. (1991) Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. Diabetes. 40: 82-87. Romijn JA, Klein S, Coyle EF, Sidossis LS, Wolfe RR. （1993）Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest. J Appl Physiol. 75: 108-113. Simsolo RB, Ong JM, Kern PA.（1993）The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining. J Clin Ivest 92: 2124-2130. Stoecker BJ. (1990) Chromium. In: Brown ML, ed. Present knowledge in nutrition. International Life Sciences Institute Nutrition Foundation. Washington, USA. pp. 287-293. Suzuki M, Doi T, Lee SJ, Okamura K, Shimizu S, Okano G, Sato Y, Shimomura Y, Fushiki T.（1999）Effect of meal timing after resistance exercise on hindlimb muscle mass and fat accumulation in trained rats. J Nutr Sci Vitaminol. 45: 401-9. Uusitupa M, Siitonen O, Harkonen M, Gordin A, Aro A, Hersio K, Johansson G, Korhonen T, Rauramaa R. (1982) Metabolic and hormonal response to physical exercise during beta 1-selective and non-selective beta-blockade. Horm Metab Res. 14: 583-588. Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR Jr. (1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 99: 385-390. Vincent JB. (2000) The biochemistry of chromium. J Nutri. 130: 715-718. Wade CE. (1984) Response, regulation, and actions of vasopressin during exercise: A review. Med Sci Sports Exerc. 16: 506-511. Wajchenberg BL. (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev. 21: 697-738. Wojtaszewski JF, Higaki Y, Hirshman MF, Michael MD, Dufresne SD, Kahn CR, Goodyear LJ. (1999) Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. J Clin Invest. 104: 1257-1264. Yamamoto A, Wada O, Ono T. (1987) Isolation of a biologically active low-molecular-mass chromium compound from rabbit liver. Eur J Biochem. 165: 627-631. Zavaroni I, Bonora E, Pagliara M, Dall''aglio E, Luchetti L, Buonanno G, Bonati PA, Bergonzani M, GnudiL, Passeri M, Reaven G. (1989) Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Eng J Med. 320: 702-706.||摘要:||
肥胖會造成或惡化許多流行性老化非傳染性疾病，目前己知肥胖症會促使代謝症候群與第二型糖尿病的發生，適當的運動是改善高血糖症狀的方法之一，鉻元素已被證實為胰島素作用的輔因子，可協助細胞內運送葡萄糖代謝，故本實驗為利用飲食誘導肥胖C57BL/6JNarl小鼠，探討規律運動改善代謝異常與體內鉻元素之變化，隨機分組成一次中度運動組、isoproterenol 3 mg/kg組、一次中度運動後propranolol 3 mg/kg組、規律運動組及控制組。結果顯示一次中度運動及isoproterenol會造成升血糖並使肝臟中鉻元素顯著的流失(p<0.05)，然而使用propranolol抑制運動後又會使血糖顯著的平緩並且減少肝臟鉻元素流失，在規律運動後小鼠的禁食血糖、禁食體重及副睪脂肪總重皆顯著的低於控制組，且造成肝臟及肌肉中鉻儲存量增加。綜合上述結果推測beta腎上腺素的活化會造成高血糖及促使肝臟鉻流失且腎臟及尿液中的鉻排泄增多，在於一次中度運動後發生同樣的情形，然而小鼠規律運動後會促使肝臟及肌肉組織的鉻儲存增加，可能是為了供給運動改善細胞能量之利用。
Obesity causes or exacerbates many health problems. It is now clear that obesity promotes the development of metabolic syndrome and type 2 diabetes. Regular exercise is known to effectively improve hyperglycemia symptom. Chromium has proven to be a cofactor for insulin action, it facilitates the movement of glucose into cells. The objectives of this study are to evaluate whether exercise can alleviate metabolic disorder and alter chromium distribution. Male C57BL/6JNarl mice fed with high fat-diet, were randomly divided into five groups: short term exercise group, isoproterenol 3 mg/kg group, propranolol 3 mg/kg after short term exercise group, long term exercise group and control group. As a result, short term exercise and isoproterenol increased blood glucose, and the contents of Cr in liver were significantly decreased (p<0.05). Propranolol can significantly reduced blood glucose elevation and decrease hepatic Cr loss. The fasting blood glucose, fasting body weight and epididymal fat weight were lower in long term exercise group than that of the control mice. The level of Cr in liver and muscle is increased after long term exercise. In conclusion, the increased blood glucose by isoproterenol stimulation decreased the Cr level in liver, and increased the Cr level in kidney and urine. Similar results were also found after a short term exercise. However, long term exercise reversed the effect by increasing Cr accumulation in liver and muscle. It suggested that the mechanism by which exercise improves insulin response may involve an alteration in Cr distribution.
|Appears in Collections:||獸醫學系所|
Show full item record
TAIR Related Article
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.